Norplant® implants and progesterone vaginal rings do not affect maternal bone turnover and density during lactation and after weaning

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dc.contributor.authorDíaz, S
dc.contributor.authorReyes, MV
dc.contributor.authorZepeda, A
dc.contributor.authorGonzález, GB
dc.contributor.authorLópez, JM
dc.contributor.authorCampino, C
dc.contributor.authorCroxatto, HB
dc.date.accessioned2025-01-21T01:31:51Z
dc.date.available2025-01-21T01:31:51Z
dc.date.issued1999
dc.description.abstractBone density and turnover was assessed in a longitudinal study of healthy lactating women who initiated use of Norplant(R) implants (NOR, n = 29), progesterone vaginal rings (PVR, n = 28) or Copper T 380A intrauterine devices (T-Cu, n = 51, control group) around day 60 postpartum. Bone density, serum calcium, phosphorus, alkaline phosphatases, parathyroid hormone (PTH), follicle stimulating hormone (FSH), oestradiol and prolactin, and urinary hydroxyproline and creatinine were measured at postpartum months 1 (PM1), and 12 (PM12) and 6 or 12 months after weaning; at month 6 postpartum (PM6) serum and urine tests alone were performed. Baseline characteristics and lactation performance were similar between groups. Biochemical markers of bone turnover were higher at PM1, PM6 and PM12 than after weaning, with no differences between groups. Bone density in the lumbar spine (L2-L4) and femoral neck at PM1 and PM12 (similar to 1.11 g/cm(2)) was similar in three groups. Lumbar spine values were found to be lower in lactating women than those present in nonlactating women, but increased after weaning to similar values, The two progestin-only contraceptives studied appear to have no deleterious effect upon bone density and metabolism in healthy lactating women.
dc.fuente.origenWOS
dc.identifier.issn0268-1161
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97155
dc.identifier.wosidWOS:000083171700019
dc.issue.numero10
dc.language.isoen
dc.pagina.final2505
dc.pagina.inicio2499
dc.revistaHuman reproduction
dc.rightsacceso restringido
dc.subjectbone density
dc.subjectbone metabolism
dc.subjectlactation
dc.subjectNorplant (R) implants
dc.subjectprogesterone rings
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleNorplant® implants and progesterone vaginal rings do not affect maternal bone turnover and density during lactation and after weaning
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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