CATABOLISM OF CHYLOMICRON REMNANTS IN PATIENTS WITH PREVIOUS ACUTE-PANCREATITIS

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dc.contributor.authorROLLAN, A
dc.contributor.authorGUZMAN, S
dc.contributor.authorPIMENTEL, F
dc.contributor.authorNERVI, F
dc.date.accessioned2025-01-23T19:23:12Z
dc.date.available2025-01-23T19:23:12Z
dc.date.issued1990
dc.description.abstractA recent study reports that patients with previous acute pancreatitis commonly have an abnormal clearance of serum triglycerides after an oral fat load. This observation supports the hypothesis that patients with previous acute pancreatitis and normal fasting serum triglyceride levels may have a preexistent abnormality in the metabolism of chylomicrons. To test this hypothesis, the catabolism of chylomicrons and their remnants was studied in a series of 7 patients who had sustained an attack of pancreatitis (2, gallstone related; 2, alcohol ingestion; 1, hydatid cyst; and 3, no associated pathological condition) at least 18 mo earlier. All the patients had previously had abnormal oral-fat tolerance test results. These patients were compared with a series of 6 healthy volunteers. Chylomicrons were endogenously labeled with an oral dose of retinyl palmitate, and their plasma elimination half-life was calculated. The retinyl palmitate absorption rate constants were similar in control and pancreatitis patients. The chylomicron t1/2 were 2.3 .+-. 0.8 (SD) h and 3.9 .+-. 1.8 h in the control and pancreatitis groups, respectively (p = 0.07). The chylomicron remnant t1/2 was 2.7 .+-. 1.1 h in the control groups and 5.2 .+-. 2.4 h in the pancreatitis group (p < 0.05). This study support the hypothesis that subjects with previous acute pancreatitis may have an abnormality in the catabolism of chylomicron particles. This abnormality may represent a preexistent genetic condition expressed in either the apoprotein composition of chylomicrons or in the hepatic apolipoprotein E-receptor activity.
dc.fuente.origenWOS
dc.identifier.eissn1528-0012
dc.identifier.issn0016-5085
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99177
dc.identifier.wosidWOS:A1990DD18000036
dc.issue.numero6
dc.language.isoen
dc.pagina.final1654
dc.pagina.inicio1649
dc.revistaGastroenterology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCATABOLISM OF CHYLOMICRON REMNANTS IN PATIENTS WITH PREVIOUS ACUTE-PANCREATITIS
dc.typeartículo
dc.volumen98
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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