HELICOBACTER-PYLORI-ASSOCIATED GASTRODUODENAL DISEASE IN SYMPTOMATIC CHILEAN CHILDREN - DIAGNOSTIC-VALUE OF SEROLOGICAL ASSAY

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dc.contributor.authorHODGSON, MI
dc.contributor.authorPANTOJA, T
dc.contributor.authorLATORRE, JJ
dc.contributor.authorVIAL, P
dc.contributor.authorHENRIQUEZ, A
dc.contributor.authorWENGER, J
dc.contributor.authorPENA, Y
dc.contributor.authorSIRI, MT
dc.contributor.authorGUIRALDES, E
dc.date.accessioned2024-01-10T12:05:46Z
dc.date.available2024-01-10T12:05:46Z
dc.date.issued1995
dc.description.abstractA newly developed enzyme-linked immunosorbent assay (ELISA) IgG serological assay for the diagnosis of Helicobacter pylori infection was used recently in two epidemiological surveys in Chile. To evaluate the diagnostic efficacy of this assay in a local symptomatic pediatric population, we studied 70 school-age patients referred for upper gastrointestinal endoscopy because of complaints suggestive of gastroduodenal disease. Evidence for antral H. pylori infection was sought by three biopsy-related methods: culture, histology, and urease activity. IgG anti-H. pylori serum antibodies were deter mined by ELISA. Altogether, chronic antral gastritis was found in 55 patients and duodenal ulcers in nine; 11 subjects had normal histology. Sixty (86%) patients had H. pylori in the antrum. This group had significantly higher mean IgG optical density values when compared with the H. pylori-negative group (1.860 versus 0.669; p < 0.001). The sensitivity and specificity of the assay in detecting antral H. pylori were both 90%; the positive predictive value was 98% and the negative, 60%. Accuracy of the assay was superior in predicting the presence or absence of gastroduodenal lesions with a sensitivity of 96%, a specificity of 92%, a positive predictive value of 98%, and a negative predictive value of 86%. We conclude that the diagnostic efficiency of this assay renders it appropriate both to screen for H. pylori-associated gastroduodenal disease in individual patients and to be used in seroepidemiological surveys.
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/00005176-199510000-00003
dc.identifier.issn0277-2116
dc.identifier.pubmedidMEDLINE:8523209
dc.identifier.urihttps://doi.org/10.1097/00005176-199510000-00003
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76065
dc.identifier.wosidWOS:A1995RX43000003
dc.information.autorucMedicina;Guiraldes E;S/I;98921
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final268
dc.pagina.inicio263
dc.publisherLIPPINCOTT-RAVEN PUBL
dc.revistaJOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
dc.rightsacceso restringido
dc.subjectHELICOBACTER PYLORI
dc.subjectELISA
dc.subjectGASTRITIS
dc.subjectSEROLOGY
dc.subjectCHILDREN
dc.subjectCHILEAN
dc.subjectCAMPYLOBACTER-PYLORI
dc.subjectGASTRIC-CARCINOMA
dc.subjectABDOMINAL-PAIN
dc.subjectINFECTION
dc.subjectPREVALENCE
dc.subjectCANCER
dc.subjectRISK
dc.subjectSEROPOSITIVITY
dc.subjectSEROPREVALENCE
dc.subjectEPIDEMIOLOGY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHELICOBACTER-PYLORI-ASSOCIATED GASTRODUODENAL DISEASE IN SYMPTOMATIC CHILEAN CHILDREN - DIAGNOSTIC-VALUE OF SEROLOGICAL ASSAY
dc.typeartículo
dc.volumen21
sipa.codpersvinculados98921
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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