Gallstone disease: From genes to evidence-based therapy
| dc.catalogador | jlo | |
| dc.contributor.author | Lammert, Frank | |
| dc.contributor.author | Miquel Poblete, Juan Francisco | |
| dc.date.accessioned | 2024-08-06T19:59:22Z | |
| dc.date.available | 2024-08-06T19:59:22Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | The number of gallstone patients is increasing in ageing populations with a high prevalence of metabolic syndrome and obesity. Recently variants of hepatic ATP binding cassette transporters have been identified as genetic susceptibility factors for gallstone disease, pointing to novel means for risk assessment and prevention. Although laparoscopic cholecystectomy is the mainstay of therapy for symptomatic gallbladder stones, the clinical management of gallstone disease is changing rapidly, with an increase in day case surgery and the advent of transluminal endoscopic surgery. Here, we summarize the molecular and genetic mechanisms of gallstone formation as well as the current evidence-based algorithms for diagnosis and therapy of gallbladder and bile duct stones. (c) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. | |
| dc.description.funder | FONDECYT | |
| dc.format.extent | 12 páginas | |
| dc.fuente.origen | Historial Académico | |
| dc.identifier.doi | 10.1016/j.jhep.2008.01.012 | |
| dc.identifier.issn | 0168-8278 | |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.jhep.2008.01.012 | |
| dc.identifier.uri | https://repositorio.uc.cl/handle/11534/87297 | |
| dc.identifier.wosid | WOS:000255425200010 | |
| dc.information.autoruc | Escuela de Medicina; Miquel Poblete, Juan Francisco; 0000-0002-0526-4377; 72216 | |
| dc.language.iso | en | |
| dc.nota.acceso | contenido parcial | |
| dc.pagina.final | S135 | |
| dc.pagina.inicio | S124 | |
| dc.revista | Journal of Hepatology | |
| dc.rights | acceso restringido | |
| dc.subject | ABC transporter | |
| dc.subject | Association study | |
| dc.subject | Bile duct stone | |
| dc.subject | Cholecystectomy | |
| dc.subject.ddc | 610 | |
| dc.subject.dewey | Medicina y salud | es_ES |
| dc.subject.ods | 03 Good health and well-being | |
| dc.subject.odspa | 03 Salud y bienestar | |
| dc.title | Gallstone disease: From genes to evidence-based therapy | |
| dc.type | artículo | |
| dc.volumen | 48 | |
| sipa.codpersvinculados | 72216 | |
| sipa.trazabilidad | Historial Académico;09-07-2021 |