Sleep dysregulation in sympathetic-mediated diseases: implications for disease progression

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dc.contributor.authorJose Olivares, Maria
dc.contributor.authorToledo, Camilo
dc.contributor.authorOrtolani, Domiziana
dc.contributor.authorOrtiz, Fernando C.
dc.contributor.authorDiaz, Hugo S.
dc.contributor.authorIturriaga, Rodrigo
dc.contributor.authorDel Rio, Rodrigo
dc.date.accessioned2025-01-20T21:03:37Z
dc.date.available2025-01-20T21:03:37Z
dc.date.issued2022
dc.description.abstractThe autonomic nervous system (ANS) plays an important role in the coordination of several physiological functions including sleep/wake process. Significant changes in ANS activity occur during wake-to-sleep transition maintaining the adequate cardiorespiratory regulation and brain activity. Since sleep is a complex homeostatic function, partly regulated by the ANS, it is not surprising that sleep disruption trigger and/or evidence symptoms of ANS impairment. Indeed, several studies suggest a bidirectional relationship between impaired ANS function (i.e. enhanced sympathetic drive), and the emergence/development of sleep disorders. Furthermore, several epidemiological studies described a strong association between sympathetic-mediated diseases and the development and maintenance of sleep disorders resulting in a vicious cycle with adverse outcomes and increased mortality risk. However, which and how the sleep/wake control and ANS circuitry becomes affected during the progression of ANS-related diseases remains poorly understood. Thus, understanding the physiological mechanisms underpinning sleep/wake-dependent sympathetic modulation could provide insights into diseases involving autonomic dysfunction. The purpose of this review is to explore potential neural mechanisms involved in both the onset/maintenance of sympathetic-mediated diseases (Rett syndrome, congenital central hypoventilation syndrome, obstructive sleep apnoea, type 2 diabetes, obesity, heart failure, hypertension, and neurodegenerative diseases) and their plausible contribution to the generation of sleep disorders in order to review evidence that may serve to establish a causal link between sleep disorders and heightened sympathetic activity.
dc.fuente.origenWOS
dc.identifier.doi10.1093/sleep/zsac166
dc.identifier.eissn1550-9109
dc.identifier.issn0161-8105
dc.identifier.urihttps://doi.org/10.1093/sleep/zsac166
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93160
dc.identifier.wosidWOS:000838254100001
dc.issue.numero11
dc.language.isoen
dc.revistaSleep
dc.rightsacceso restringido
dc.subjectsleep regulation
dc.subjectautonomic nervous system
dc.subjectarousal
dc.subjectsympathetic hyperactivity
dc.subjectsympathetic-mediated diseases
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSleep dysregulation in sympathetic-mediated diseases: implications for disease progression
dc.typeartículo
dc.volumen45
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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