Case report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration

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dc.catalogadorjwg
dc.contributor.authorObaid, Miguel L.
dc.contributor.authorCarvajal Diaz, Felipe Alonso
dc.contributor.authorCamacho, Juan Pablo
dc.contributor.authorCorrales-Oravio, Rocio
dc.contributor.authorMartorell, Ximena
dc.contributor.authorVaras, Juan
dc.contributor.authorCalderon, Wilfredo
dc.contributor.authorDani Guzman, Christian
dc.contributor.authorBrenet, Marianne
dc.contributor.authorCastro, Margarita
dc.contributor.authorOrlandi, Cecilia
dc.contributor.authorSan Martin, Sebastian
dc.contributor.authorEblen Zajjur Antonio Alejandro
dc.contributor.authorEgaña Erazo, José Tomás
dc.date.accessioned2024-01-29T19:36:28Z
dc.date.available2024-01-29T19:36:28Z
dc.date.issued2022
dc.description.abstractIt is broadly described that almost every step of the regeneration process requires proper levels of oxygen supply; however, due to the vascular disruption in wounds, oxygen availability is reduced, being detrimental to the regeneration process. Therefore, the development of novel biomaterials combined with improved clinical procedures to promote wound oxygenation is an active field of research in regenerative medicine. This case report derives from a cohort of patients enrolled in a previously published ongoing phase I clinical trial (NCT03960164), to assess safety of photosynthetic scaffolds for the treatment of full skin defects. Here, we present a 56 year old patient, with a scar contracture in the cubital fossa, which impaired the elbow extension significantly affecting her quality of life. As part of the treatment, the scar contracture was removed, and the full-thickness wound generated was surgically covered with a photosynthetic scaffold for dermal regeneration, which was illuminated to promote local oxygen production. Then, in a second procedure, an autograft was implanted on top of the scaffold and the patient's progress was followed for up to 17 months. Successful outcome of the whole procedure was measured as improvement in functionality, clinical appearance, and self-perception of the treated area. This case report underscores the long-term safety and applicability of photosynthetic scaffolds for dermal regeneration and their stable compatibility with other surgical procedures such as autograft application. Moreover, this report also shows the ability to further improve the clinical outcome of this procedure by means of dermal vacuum massage therapy and, more importantly, shows an overall long-term improvement in patient & PRIME;s quality of life, supporting the translation of photosynthetic therapies into human patients.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fbioe.2022.1004155
dc.identifier.issn2296-4185
dc.identifier.urihttps://doi.org/10.3389/fbioe.2022.1004155
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81044
dc.identifier.wosidWOS:000899052800001
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Egaña Erazo Jose Tomas; 0000-0003-2624-6992; 1018715
dc.information.autorucFacultad de Ciencias Biológicas; Carvajal Diaz Felipe Alonso; ; 171996
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Eblen Zajjur Antonio Alejandro; ; 1051050
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherFRONTIERS MEDIA SA
dc.revistaFrontiers in Bioengineering and Biotechnology
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods06 Clean water and sanitation
dc.subject.odspa06 Agua limpia y saneamiento
dc.titleCase report: Long-term follow-up of a large full-thickness skin defect treated with a photosynthetic scaffold for dermal regeneration
dc.typeinforme
dc.volumen10
sipa.codpersvinculados1018715
sipa.codpersvinculados171996
sipa.codpersvinculados1051050
sipa.trazabilidadORCID;2024-01-15
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