Elastin-specific MR probe for visualization and evaluation of an interleukin-1β targeted therapy for atherosclerosis

Simple item page
dc.contributor.authorMangarova, Dilyana Branimirova
dc.contributor.authorReimann, Carolin
dc.contributor.authorKaufmann, Jan Ole
dc.contributor.authorMoeckel, Jana
dc.contributor.authorKader, Avan
dc.contributor.authorAdams, Lisa Christine
dc.contributor.authorLudwig, Antje
dc.contributor.authorOnthank, David
dc.contributor.authorRobinson, Simon
dc.contributor.authorKarst, Uwe
dc.contributor.authorHelmer, Rebecca
dc.contributor.authorBotnar, Rene
dc.contributor.authorHamm, Bernd
dc.contributor.authorMakowski, Marcus Richard
dc.contributor.authorBrangsch, Julia
dc.date.accessioned2025-01-20T16:08:50Z
dc.date.available2025-01-20T16:08:50Z
dc.date.issued2024
dc.description.abstractAtherosclerosis is a chronic inflammatory condition of the arteries and represents the primary cause of various cardiovascular diseases. Despite ongoing progress, finding effective anti-inflammatory therapeutic strategies for atherosclerosis remains a challenge. Here, we assessed the potential of molecular magnetic resonance imaging (MRI) to visualize the effects of 01BSUR, an anti-interleukin-1 beta monoclonal antibody, for treating atherosclerosis in a murine model. Male apolipoprotein E-deficient mice were divided into a therapy group (01BSUR, 2 x 0.3 mg/kg subcutaneously, n = 10) and control group (no treatment, n = 10) and received a high-fat diet for eight weeks. The plaque burden was assessed using an elastin-targeted gadolinium-based contrast probe (0.2 mmol/kg intravenously) on a 3 T MRI scanner. T1-weighted imaging showed a significantly lower contrast-to-noise (CNR) ratio in the 01BSUR group (pre: 3.93042664; post: 8.4007067) compared to the control group (pre: 3.70679168; post: 13.2982156) following administration of the elastin-specific MRI probe (p < 0.05). Histological examinations demonstrated a significant reduction in plaque size (p < 0.05) and a significant decrease in plaque elastin content (p < 0.05) in the treatment group compared to control animals. This study demonstrated that 01BSUR hinders the progression of atherosclerosis in a mouse model. Using an elastin-targeted MRI probe, we could quantify these therapeutic effects in MRI.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-024-71716-5
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-024-71716-5
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90110
dc.identifier.wosidWOS:001306841300036
dc.issue.numero1
dc.language.isoen
dc.revistaScientific reports
dc.rightsacceso restringido
dc.subjectAtherosclerosis
dc.subjectMolecular imaging
dc.subjectElastin
dc.subjectPlaque
dc.subjectInterleukin-1beta
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleElastin-specific MR probe for visualization and evaluation of an interleukin-1β targeted therapy for atherosclerosis
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas