Comprehensive 3D Free-Breathing MRI for Simultaneous Myocardial Viability and Coronary Artery Visualization at 1.5T and 3T
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Date
2025
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Abstract
BACKGROUND: Cardiovascular magnetic resonance is promising for non-invasive assessment of various cardiac diseases with the ability to provide multi-contrast images including late gadolinium enhancement (LGE) for myocardial tissue characterization and coronary magnetic resonance angiography (CMRA) for anatomical imaging. However, LGE and CMRA are usually acquired separately in clinical routine with unmatched spatial resolution and slice positions. In this study, we aim to achieve a one-stop imaging of 3D grey-blood phase sensitive inversion recovery (PSIR) LGE and 3D CMRA by proposing a free-breathing simultaneous Grey-Blood and Bright-blOOd phase SensiTive inversion recovery (GB-BOOST) sequence. METHODS: The proposed research sequence acquires two interleaved 3D volumes with inversion recovery and T2 preparation pulses to obtain grey-blood PSIR and CMRA, respectively. Two-dimensional image navigator (iNAV) is performed before the acquisition of each volume to detect respiratory motion, enabling free-breathing acquisition with 100% respiratory scan efficiency. The GB-BOOST framework is compatible with both Dixon gradient echo (GRE) and balanced steady-state free precession (bSSFP) sequences for the application at 3T and 1.5T. In-vivo validation experiments included in total 23 patients for GB-BOOST, which were performed on either a 3T or a 1.5T clinical scanner. The performance of the proposed sequence was compared with clinical 2D grey-blood PSIR and free-breathing 3D CMRA. RESULTS: GB-BOOST was successfully performed on all 23 patients and was able to efficiently acquire intrinsically co-registered 3D PSIR and CMRA images with 1.2 mm 3 resolution in 9.4 ± 1.3mins. Compared with 2D grey-blood PSIR, 3D PSIR GB-BOOST had comparable scar area detection performance without significant differences in image contrast of scar-to-blood (0.42±0.40 vs. 0.30±0.43, p = 0.38), scar-to-myocardium (1.09±0.27 vs. 1.02±0.32, p = 0.30), and blood-to-myocardium (0.67±0.19 vs. 0.72±0.23, p = 0.56). Compared with single-contrast 3D CMRA sequence, 3D T2prep GB-BOOST showed comparable image quality and quantitative vessel metrics of coronary arteries. CONCLUSION: The proposed GB-BOOST sequence can achieve simultaneous co-registered 3D whole-heart grey-blood PSIR and CMRA in a single scan with image contrast and image quality comparable with separately acquired images.
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Keywords
Late gadolinium enhancement, Coronary magnetic resonance angiography, 3D whole-heart, Coronary artery disease, Multi-contrast