Evolution of lysine-specific demethylase 1 and REST corepressor gene families and their molecular interaction

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dc.contributor.authorOlivares-Costa, Montserrat
dc.contributor.authorOyarzun, Gianluca Merello
dc.contributor.authorVerbel-Vergara, Daniel
dc.contributor.authorGonzalez, Marcela P.
dc.contributor.authorArancibia, Duxan
dc.contributor.authorAndres, Maria E.
dc.contributor.authorOpazo, Juan C.
dc.date.accessioned2025-01-20T17:21:01Z
dc.date.available2025-01-20T17:21:01Z
dc.date.issued2023
dc.description.abstractLysine-specific demethylase 1A (LSD1) binds to the REST corepressor (RCOR) protein family of corepressors to erase transcriptionally active marks on histones. Functional diversity in these complexes depends on the type of RCOR included, which modulates the catalytic activity of the complex. Here, we studied the duplicative history of the RCOR and LSD gene families and analyzed the evolution of their interaction. We found that RCOR genes are the product of the two rounds of whole-genome duplications that occurred early in vertebrate evolution. In contrast, the origin of the LSD genes traces back before to the divergence of animals and plants. Using bioinformatics tools, we show that the RCOR and LSD1 interaction precedes the RCOR repertoire expansion that occurred in the last common ancestor of jawed vertebrates. Overall, we trace LSD1-RCOR complex evolution and propose that animal non-model species offer advantages in addressing questions about the molecular biology of this epigenetic complex.
dc.description.abstractA study of the evolution of the RCOR-LSD1 epigenetic complex sheds light on its evolutionary origin, the role of whole genome duplications in its evolution, and the conservation of the structure of the protein complex in the gnathostome ancestor.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s42003-023-05652-x
dc.identifier.eissn2399-3642
dc.identifier.urihttps://doi.org/10.1038/s42003-023-05652-x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91444
dc.identifier.wosidWOS:001125186300003
dc.issue.numero1
dc.language.isoen
dc.revistaCommunications biology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEvolution of lysine-specific demethylase 1 and REST corepressor gene families and their molecular interaction
dc.typeartículo
dc.volumen6
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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