Clinical Research Regional Vascular Changes and Aortic Dilatation in Pediatric Patients With Bicuspid Aortic Valve

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dc.contributor.authorRumman, Rawan K.
dc.contributor.authorSlorach, Cameron
dc.contributor.authorHui, Wei
dc.contributor.authorLopez, Carmen
dc.contributor.authorLarios, Guillermo
dc.contributor.authorFan, Steve
dc.contributor.authorFranco-Cereceda, Anders
dc.contributor.authorLoeys, Bart
dc.contributor.authorMohamed, Salah A.
dc.contributor.authorDietz, Harry
dc.contributor.authorMital, Seema
dc.contributor.authorAndelfinger, Gregor
dc.contributor.authorMertens, Luc
dc.contributor.authorGrattan, Michael
dc.date.accessioned2025-01-20T21:02:59Z
dc.date.available2025-01-20T21:02:59Z
dc.date.issued2022
dc.description.abstractBackground: Bicuspid aortic valve (BAV) is the most common congenital heart disease, often associated with valve dysfunction, coarctation of the aorta, and ascending aorta dilatation. Aortic dilatation might result from abnormal regional hemodynamics or inherent vascular disease. Vascular function in pediatric BAV remains poorly characterized.
dc.description.abstractMethods: A cross-sectional study was performed to evaluate vascular function in 142 children with BAV aged 7-18 years compared with healthy control children. Echocardiography was performed to assess aortic dimensions, BAV function, and vascular function (aortic arch pulse wave velocity [PWV]), carotid intima media thickness, and aortic stiffness and distensibility). Carotid-femoral and carotid-radial PWV were assessed using tonometry. Vascular function was compared for 4 patient groups stratified according to aortic dilatation and a history of coarctation of the aorta. Multivariate regression analysis was per-formed to determine predictors of aortic dilatation.
dc.description.abstractResults: Children with BAV had stiffer and less distensible ascending aortas with higher aortic arch PWV compared with control children. Carotid-femoral and carotid-radial PWV were not increased in patients with BAV, and the vascular assessment of the abdominal aorta was unremarkable. Multivariate regression revealed that aortic arch PWV was the only vascular function parameter that was associated with aortic dilatation.
dc.description.abstractConclusions: Children with BAV have differences in vascular function that are confined to their proximal aorta, even in normal functioning BAV. The observed differences in vascular function are likely multi-factorial, with contributions from abnormal regional flow and a potential localized primary aortopathy.
dc.description.funderFondation Leducq Network Grant
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.cjca.2022.01.020
dc.identifier.eissn1916-7075
dc.identifier.issn0828-282X
dc.identifier.urihttps://doi.org/10.1016/j.cjca.2022.01.020
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93111
dc.identifier.wosidWOS:000841497900015
dc.issue.numero5
dc.language.isoen
dc.pagina.final694
dc.pagina.inicio688
dc.revistaCanadian journal of cardiology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical Research Regional Vascular Changes and Aortic Dilatation in Pediatric Patients With Bicuspid Aortic Valve
dc.typeartículo
dc.volumen38
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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