A new equation to estimate daily natriuresis from parameters in plasma and spot urine sample in the Chilean populationNueva ecuación para la estimación de la natriuresis diaria a partir de parámetros en plasma y orina aislada en población chilena

Simple item page
dc.article.number678480
dc.contributor.authorSepúlveda R.A.
dc.contributor.authorHuidobro E J.P.
dc.contributor.authorJara A.
dc.contributor.authorTagle R.
dc.date.accessioned2025-05-01T10:32:30Z
dc.date.available2025-05-01T10:32:30Z
dc.date.issued2021
dc.description.abstractBACKGROUND: Excessive sodium intake is associated with increased cardiovascular morbidity and mortality. Daily sodium intake is usually inferred from sodium excretion in a 24-hour urine collection, which is cumbersome and prone to errors. Different formulas have attempted to estimate 24-hour urinary sodium from a spot urine sample. Unfortunately, their concordances are insufficient and have not been tested in our population. AIM: To develop an equation to predict 24-hour urine sodium from parameters in plasma and spot urine samples. To validate the equation and compare it with other formulas in Chilean population. MATERIAL AND METHODS: Analysis of 24-hour urine collections, plasma sample and spot urine sample from 174 adult outpatients (81% females) with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73m2. These were collected between 2015 and 2019 using standardized methods and educating patients about the correct method to collect 24 h urine samples. In all these patients, creatinine and electrolytes were measured in plasma and urine. A new equation was developed using a multiple linear regression model. RESULTS: Twenty-four-hour urine sodium excretion was significantly correlated with age, weight, height, eGFR, plasma osmolarity, urine electrolytes and parameters obtained from spot urine sample, among others. The new equation had a linear correlation with 24-hour natriuresis of 0.91 and the concordance was 0.9. The predictive capacity of the new equation was better than the existing formulas. CONCLUSIONS: We developed a formula to accurately predict daily natriuresis in the Chilean population.
dc.description.funderGerman Centre for Integrative Biodiversity Research
dc.description.funderScientific Grant Agency VEGA
dc.description.funderUNILEVER
dc.description.funderEuropean Union’s Horizon 2020 Research and Innovation Program
dc.description.funderCESAM
dc.description.funderEuropean Research Council
dc.description.funderGerman Research Foundation
dc.description.funderFCT
dc.description.funderMCTES
dc.description.funderFCT-Foundation for Science and Technology
dc.description.funderiDiv
dc.format.extent186 páginas
dc.fuente.origenScopus
dc.identifier.doi10.4067/s0034-98872021000200178
dc.identifier.eisbn978-1-0716-1534-8
dc.identifier.eissn07176163
dc.identifier.isbn978-1-0716-1533-1
dc.identifier.issn07176163
dc.identifier.pubmedid34479261
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85115757339
dc.identifier.urihttps://doi.org/10.4067/s0034-98872021000200178
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103857
dc.identifier.wosidWOS:001066054800017
dc.information.autorucEscuela de Medicina; Sepulveda Palamara Rodrigo Andres; 0000-0002-9618-3686; 252768
dc.information.autorucEscuela de Medicina; Jara Contreras Aquiles Elias; S/I; 99877
dc.information.autorucEscuela de Medicina; Tagle Vargas Rodrigo Jaime; 0000-0002-7756-7190; 59867
dc.information.autorucEscuela de Medicina; Huidobro Espinosa Juan Pablo; 0000-0002-5717-1017; 149948
dc.issue.numero2
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final186
dc.pagina.inicio178
dc.publisherHUMANA PRESS INC
dc.relation.ispartofRevista medica de Chile
dc.revistaRevista medica de Chile
dc.rightsAcceso abierto
dc.subjectCritical Care
dc.subjectDelirium
dc.subjectHypnotics and Sedatives
dc.subjectNeuromuscular Blockade
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA new equation to estimate daily natriuresis from parameters in plasma and spot urine sample in the Chilean populationNueva ecuación para la estimación de la natriuresis diaria a partir de parámetros en plasma y orina aislada en población chilena
dc.typeartículo
dc.volumen149
sipa.codpersvinculados252768
sipa.codpersvinculados99877
sipa.codpersvinculados59867
sipa.codpersvinculados149948
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
Files
Collections
Artículos de revistas