TOTAL SIALIC-ACID IN HUMAN AND CANINE PLATELETS DOES NOT CHANGE WITH THE PLATELET AGE

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dc.contributor.authorMEZZANO, D
dc.contributor.authorARANDA, E
dc.contributor.authorGARCIA, ME
dc.contributor.authorPEREIRA, J
dc.contributor.authorQUIROGA, T
dc.contributor.authorPEREZ, M
dc.date.accessioned2024-01-10T14:22:15Z
dc.date.available2024-01-10T14:22:15Z
dc.date.issued1992
dc.description.abstractTotal platelet sialic acid (SA) was measured in three experimental conditions: (1) human and canine platelet density subpopulations obtained by centrifugation in arabinogalactan gradients, (2) circulating canine platelets during recovery from experimental immune and mechanical thrombocytopenias, and (3) platelets obtained from a patient with chronic immune thrombocytopenic purpura before and after splenectomy. The density of human and canine platelets is, in part, determined by their age. We found no significant differences in total SA between high-density (HD) and low-density (LD) platelets (9.32 +/- 2.0 vs. 9.55 +/- 1.3-mu-g/mg of platelet protein in dogs and 9.02 +/- 2.3 vs. 9.10 +/- 2.9 mu-g/mg in humans). In the human and canine thrombocytopenic models, the entrance of new platelets from the bone marrow is followed by their aging in the circulation. In these models, no significant changes in total SA content were detected in sequential measurements during the recovery of the thrombocytopenia. Accordingly, we conclude that total SA in human and canine platelets is unrelated to their age in circulation. These results do not support the notion that the loss of SA from membrane glycoproteins determines the recognition and removal of platelets from the circulation.
dc.fechaingreso.objetodigital02-04-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/ajh.2830400103
dc.identifier.issn0361-8609
dc.identifier.pubmedidMEDLINE:1566747
dc.identifier.urihttps://doi.org/10.1002/ajh.2830400103
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79894
dc.identifier.wosidWOS:A1992HQ20100002
dc.information.autorucMedicina;Mezzano D;S/I;99455
dc.information.autorucMedicina;Pereira J;S/I;99371
dc.information.autorucMedicina;Quiroga S;S/I;52601
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final11
dc.pagina.inicio5
dc.publisherWILEY-LISS
dc.revistaAMERICAN JOURNAL OF HEMATOLOGY
dc.rightsacceso restringido
dc.subjectPLATELET AGING
dc.subjectDENSITY
dc.subjectSIALIC ACID
dc.subjectDENSITY SUBPOPULATIONS
dc.subjectBUOYANT DENSITY
dc.subjectMEMBRANE
dc.subjectPROTEIN
dc.subjectSIZE
dc.subjectNEURAMINIDASE
dc.subjectPOPULATIONS
dc.subjectSURVIVAL
dc.subjectINCREASE
dc.subjectREMOVAL
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTOTAL SIALIC-ACID IN HUMAN AND CANINE PLATELETS DOES NOT CHANGE WITH THE PLATELET AGE
dc.typeartículo
dc.volumen40
sipa.codpersvinculados99455
sipa.codpersvinculados99371
sipa.codpersvinculados52601
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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