Dietary Fructose Promotes Prostate Cancer Growth

dc.contributor.authorCarreno, Daniela, V
dc.contributor.authorCorro, Nestor B.
dc.contributor.authorCerda-Infante, Javier F.
dc.contributor.authorEcheverria, Carolina E.
dc.contributor.authorAsencio-Barria, Catalina A.
dc.contributor.authorTorres-Estay, Veronica A.
dc.contributor.authorMayorga-Weber, Gonzalo A.
dc.contributor.authorRojas, Pablo A.
dc.contributor.authorVeliz, Loreto P.
dc.contributor.authorCisternas, Pedro A.
dc.contributor.authorMontecinos, Viviana P.
dc.contributor.authorSan Francisco, Ignacio F.
dc.contributor.authorVaras-Godoy, Manuel A.
dc.contributor.authorSotomayor, Paula C.
dc.contributor.authorCastro, Maite A.
dc.contributor.authorNualart, Francisco J.
dc.contributor.authorInestrosa, Nibaldo C.
dc.contributor.authorGodoy, Alejandro S.
dc.date.accessioned2025-01-20T22:19:48Z
dc.date.available2025-01-20T22:19:48Z
dc.date.issued2021
dc.description.abstractClinical localization of primary tumors and sites of metastasis by PET is based on the enhanced cellular uptake of 2-deoxy-2-[F-18]-fluoro-D-glucose (FDG). In prostate cancer, however, PET-FDG imaging has shown limited clinical applicability, suggesting that prostate cancer cells may utilize hexoses other than glucose, such as fructose, as the preferred energy source. Our previous studies suggested that prostate cancer cells overexpress fructose transporters, but not glucose transporters, compared with benign cells. Here, we focused on validating the functional expression of fructose transporters and determining whether fructose can modulate the biology of prostate cancer cells in vitro and in vivo. Fructose transporters, Glut5 and Glut9, were significantly upregulated in clinical specimens of prostate cancer when compared with their benign counterparts. Fructose levels in the serum of patients with prostate cancer were significantly higher than healthy subjects. Functional expression of fructose transporters was confirmed in prostate cancer cell lines. A detailed kinetic characterization indicated that Glut5 represents the main functional contributor in mediating fructose transport in prostate cancer cells. Fructose stimulated proliferation and invasion of prostate cancer cells in vitro. In addition, dietary fructose increased the growth of prostate cancer cell line-derived xenograft tumors and promoted prostate cancer cell proliferation in patient- derived xenografts. Gene set enrichment analysis confirmed that fructose stimulation enriched for proliferation-related pathways in prostate cancer cells. These results demonstrate that fructose promotes prostate cancer cell growth and aggressiveness in vitro and in vivo and may represent an alternative energy source for prostate cancer cells.
dc.description.abstractSignificance: This study identifies increased expression of fructose transporters in prostate cancer and demonstrates a role for fructose as a key metabolic substrate supporting prostate cancer cells, revealing potential therapeutic targets and biomarkers.
dc.fuente.origenWOS
dc.identifier.doi10.1158/0008-5472.CAN-19-0456
dc.identifier.eissn1538-7445
dc.identifier.issn0008-5472
dc.identifier.urihttps://doi.org/10.1158/0008-5472.CAN-19-0456
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94606
dc.identifier.wosidWOS:000659297500006
dc.issue.numero11
dc.language.isoen
dc.pagina.final2832
dc.pagina.inicio2824
dc.revistaCancer research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDietary Fructose Promotes Prostate Cancer Growth
dc.typeartículo
dc.volumen81
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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