REGULATION OF AXONAL MICROTUBULES - EFFECT OF SYMPATHETIC HYPERACTIVITY ELICITED BY RESERPINE

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dc.contributor.authorALVAREZ, J
dc.contributor.authorARREDONDO, F
dc.contributor.authorESPEJO, F
dc.contributor.authorWILLIAMS, V
dc.date.accessioned2025-01-23T19:44:10Z
dc.date.available2025-01-23T19:44:10Z
dc.date.issued1982
dc.description.abstractThe density of microtubules in sympathetic postganglionic fibers of the cat was studied with EM before and after administration of reserpine. The microtubule density was 56 microtubules/.mu.2 under basal conditions. Six hours after reserpine administration the density rose by 46%. This change was still present 55 h later. At least 31% of the total microtubular protein in the axoplasm of sympathetic fibers of the unrestrained cat was estimated to be in the soluble form. The increase in microtubule density was prevented by a section of the preganglionic fibers. Microtubules of the unmyelinated fibers of the cutaneous sural nerve were unaffected by reserpine treatment. Since reserpine produces hyperactivity of sympathetic nerves, this hyperactivity apparently is instrumental in the increase of the number of axonal microtubules. The electrical activity of nerves regulates axonal microtubules in the living animal.
dc.fuente.origenWOS
dc.identifier.eissn1873-7544
dc.identifier.issn0306-4522
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99965
dc.identifier.wosidWOS:A1982PP77900018
dc.issue.numero10
dc.language.isoen
dc.pagina.final2559
dc.pagina.inicio2551
dc.revistaNeuroscience
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleREGULATION OF AXONAL MICROTUBULES - EFFECT OF SYMPATHETIC HYPERACTIVITY ELICITED BY RESERPINE
dc.typeartículo
dc.volumen7
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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