Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles

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dc.contributor.authorCarrasco-Sandoval, Jonathan
dc.contributor.authorAranda, Mario
dc.contributor.authorHenriquez-Aedo, Karem
dc.contributor.authorFernandez, Marcos
dc.contributor.authorLopez-Rubio, Amparo
dc.contributor.authorFabra, Maria Jose
dc.date.accessioned2025-01-20T20:11:07Z
dc.date.available2025-01-20T20:11:07Z
dc.date.issued2023
dc.description.abstractThis work aimed at studying the effect of molecular weight (MW) and deacetylation degree (DD) of chitosan on the quercetin bioaccessibility encapsulated in alginate/chitosan-coated zein nanoparticles (alg/chiZN). The chitosan coating layer produced nanoparticulate systems with good stability parameters, high encapsulation efficiency (EE) and a higher bioaccessibilty of quercetin after in-vitro digestion. By increasing the DD of chitosan, the zeta-potential of the colloidal system significantly increased (>= 27.1 mV), while low and very low MW chitosans generated systems with smaller particle sizes (<= 277.8 nm) and polydispersity index [PDI (0.189)]. The best results, in terms of EE (>= 84.44) and bioaccessibility (>= 76.70), were obtained when the systems were prepared with low MW chitosan and high DD. Thus, the alg/chiZN nanocapsules may be a promising delivery system for improving the quercetin bioaccessibility or other compounds with a similar chemical nature, especially when higher DD and lower MWs are used.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ijbiomac.2023.124876
dc.identifier.eissn1879-0003
dc.identifier.issn0141-8130
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2023.124876
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92121
dc.identifier.wosidWOS:000999119100001
dc.language.isoen
dc.revistaInternational journal of biological macromolecules
dc.rightsacceso restringido
dc.subjectQuercetin
dc.subjectChitosan
dc.subjectMolecular weight
dc.subjectDeacetylation degree
dc.subjectNanoparticles
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImpact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles
dc.typeartículo
dc.volumen242
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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