LAG-3 Contribution to T Cell Downmodulation during Acute Respiratory Viral Infections

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dc.catalogadorvzp
dc.contributor.authorRodriguez Guilarte, Linmar Eri Jose
dc.contributor.authorRamirez Pozo, Mario Andres
dc.contributor.authorAndrade Parra, Catalina Andrea
dc.contributor.authorKalergis Parra Alexis Mikes
dc.date.accessioned2024-01-26T17:04:56Z
dc.date.available2024-01-26T17:04:56Z
dc.date.issued2023
dc.description.abstractLAG-3 is a type I transmembrane protein expressed on immune cells, such as activated T cells, and binds to MHC class II with high affinity. LAG-3 is an inhibitory receptor, and its multiple biological activities on T cell activation and effector functions play a regulatory role in the immune response. Immunotherapies directed at immune checkpoints, including LAG-3, have become a promising strategy for controlling malignant tumors and chronic viral diseases. Several studies have suggested an association between the expression of LAG-3 with an inadequate immune response during respiratory viral infections and the susceptibility to reinfections, which might be a consequence of the inhibition of T cell effector functions. However, important information relative to therapeutic potential during acute viral lower respiratory tract infections and the mechanism of action of the LAG-3 checkpoint remains to be characterized. In this article, we discuss the contribution of LAG-3 to the impairment of T cells during viral respiratory infections. Understanding the host immune response to respiratory infections is crucial for developing effective vaccines and therapies.
dc.fechaingreso.objetodigital2024-03-25
dc.format.extent15 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3390/v15010147
dc.identifier.eissn1999-4915
dc.identifier.urihttps://doi.org/10.3390/v15010147
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80992
dc.identifier.wosidWOS:000926169300001
dc.information.autorucFacultad de Ciencias Biológicas; Rodríguez Guilarte, Linmar Eri Jose; S/I; 1126710
dc.information.autorucFacultad de Ciencias Biológicas; Ramírez Pozo, Mario Andres; S/I; 1063387
dc.information.autorucFacultad de Ciencias Biológicas; Andrade Parra, Catalina Andrea; S/I; 234276
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final15
dc.pagina.inicio1
dc.publisherMDPI
dc.revistaVIRUSES-BASEL
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.en
dc.subjectLAG-3
dc.subjectLigand
dc.subjectT cell dysfunction
dc.subjectViral infections
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLAG-3 Contribution to T Cell Downmodulation during Acute Respiratory Viral Infections
dc.typeartículo
dc.volumen15
sipa.codpersvinculados1126710
sipa.codpersvinculados1063387
sipa.codpersvinculados234276
sipa.codpersvinculados90610
sipa.trazabilidadWOS;2023-07-06
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