Enzymes of glycolysis and the pentose phosphate pathway as targets of oxidants: Role of redox reactions on the carbohydrate catabolism

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dc.catalogadorvzp
dc.contributor.authorFuentes Lemus, Eduardo Felipe
dc.contributor.authorUsgame Fagua, Karen Gineth
dc.contributor.authorFierro Huerta, Angelica María
dc.contributor.authorLópez Alarcón, Camilo Ignacio
dc.date.accessioned2025-03-12T19:30:05Z
dc.date.available2025-03-12T19:30:05Z
dc.date.issued2025
dc.description.abstractRedox reactions can modulate metabolic and signaling pathways with consequences on cellular adaptation to different stimuli. The abundance and structural features of some metabolic enzymes make these targets of oxidants, including one- and two-electron oxidant molecules, altering their structure and/or function. Therefore, redox processes play an important role in physiology and pathology. In particular, the oxidative post- translational modification of the enzymes that participate in glycolysis and the pentose phosphate pathway (PPP) can modulate the carbon flux affecting synthesis of nucleotides, as well as production of adenosine triphosphate (ATP) and reducing equivalents (in the form of nicotinamide adenine dinucleotide phosphate, NADPH). Specifically, generation of NADPH, a cofactor important for cell homeostasis, is key to the management of the redox status of cells towards oxidative insults. In this review we discuss the available literature on the impact of oxidative post-translational modifications on key glycolytic and PPP enzymes with an analysis of the consequences these may have for cell metabolic adaptation. We also discuss the contributions of new experimental and in silico approaches to the redox biochemistry field, which have significantly illuminated the intricate relationship between the pathways involved in carbohydrate metabolism and how these could be regulated by redox reactions.
dc.fechaingreso.objetodigital2025-03-12
dc.format.extent16 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.rbc.2025.100049
dc.identifier.eissn2773-1766
dc.identifier.urihttps://doi.org/10.1016/j.rbc.2025.100049
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102544
dc.information.autorucEscuela de Química; Fuentes Lemus, Eduardo Felipe; 0000-0002-1465-8466; 186720
dc.information.autorucEscuela de Química; Usgame Fagua, Karen Gineth; S/I; 1289838
dc.information.autorucEscuela de Química; Fierro Huerta, Angelica María; 0000-0002-6507-4188; 218137
dc.information.autorucEscuela de Química; López Alarcón, Camilo Ignacio; S/I; 1004308
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaRedox Biochemistry and Chemistry
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectGlycolysis
dc.subjectPentose phosphate pathway
dc.subjectProtein oxidation
dc.subjectRedox metabolism
dc.subjectOxidants
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEnzymes of glycolysis and the pentose phosphate pathway as targets of oxidants: Role of redox reactions on the carbohydrate catabolism
dc.typeArtículo
dc.volumen11
sipa.codpersvinculados186720
sipa.codpersvinculados1289838
sipa.codpersvinculados218137
sipa.codpersvinculados1004308
sipa.trazabilidadORCID;2025-03-03
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