IN-VITRO PROGESTERONE EFFECTS ON H-3 NOREPINEPHRINE RELEASE FROM RAT CEREBRAL-CORTEX SLICES
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Date
1993
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Abstract
THE effect of progesterone in vitro (0.05-5 muM) on K+-induced, Ca2+-dependent release of H-3-NE from brain slices obtained from the occipital region of rats, during the oestrous cycle or 7 days after ovariectomy or on the fifth day of pregnancy was studied. The hormone reduced the K+ (20 mM) effect in all the stages of the cycle, but did not modify the reduced release found- after ovariectomy or pregnancy or the release induced from male slices. Yohimbine blocked the effect of progesterone. The results suggest the releasing process of norepinephrine in the cerebral cortex as a target for progesterone modulatory influences on brain function.
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Keywords
NOREPINEPHRINE RELEASE, CEREBRAL CORTEX, PROGESTERONE INFLUENCES, ESTROUS CYCLE, PREGNANCY