Autocrine/Paracrine Slit-Robo Signaling Controls Optic Lobe Development in <i>Drosophila melanogaster</i>

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dc.contributor.authorGonzalez-Ramirez, M. Constanza
dc.contributor.authorRojo-Cortes, Francisca
dc.contributor.authorCandia, Noemi
dc.contributor.authorGaray-Montecinos, Jorge
dc.contributor.authorGuzman-Palma, Pablo
dc.contributor.authorCampusano, Jorge M. M.
dc.contributor.authorOliva, Carlos
dc.date.accessioned2025-01-20T21:03:21Z
dc.date.available2025-01-20T21:03:21Z
dc.date.issued2022
dc.description.abstractCell segregation mechanisms play essential roles during the development of the central nervous system (CNS) to support its organization into distinct compartments. The Slit protein is a secreted signal, classically considered a paracrine repellent for axonal growth through Robo receptors. However, its function in the compartmentalization of CNS is less explored. In this work, we show that Slit and Robo3 are expressed in the same neuronal population of the Drosophila optic lobe, where they are required for the correct compartmentalization of optic lobe neuropils by the action of an autocrine/paracrine mechanism. We characterize the endocytic route followed by the Slit/Robo3 complex and detected genetic interactions with genes involved in endocytosis and actin dynamics. Thus, we report that the Slit-Robo3 pathway regulates the morphogenesis of the optic lobe through an atypical autocrine/paracrine mechanism in addition to its role in axon guidance, and in association with proteins of the endocytic pathway and small GTPases.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fcell.2022.874362
dc.identifier.issn2296-634X
dc.identifier.urihttps://doi.org/10.3389/fcell.2022.874362
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93141
dc.identifier.wosidWOS:000841194600001
dc.language.isoen
dc.revistaFrontiers in cell and developmental biology
dc.rightsacceso restringido
dc.subjectnervous system development
dc.subjectcell segregation
dc.subjectaxon guidance
dc.subjectslit-robo pathway
dc.subjectDrosophila melanogaster
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAutocrine/Paracrine Slit-Robo Signaling Controls Optic Lobe Development in <i>Drosophila melanogaster</i>
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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