Bedside markers of coronary artery patency and short-term prognosis of patients with acute myocardial infarction and thrombolysis

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dc.contributor.authorCorbalán, R
dc.contributor.authorPrieto, JC
dc.contributor.authorChavez, E
dc.contributor.authorNazzal, C
dc.contributor.authorCumsille, F
dc.contributor.authorKrucoff, M
dc.date.accessioned2025-01-21T01:31:54Z
dc.date.available2025-01-21T01:31:54Z
dc.date.issued1999
dc.description.abstractBackground In this study we have evaluated the prognostic power of noninvasive markers of coronary artery reperfusion in patients with acute myocardial infarction who were treated with intravenous streptokinase.
dc.description.abstractMethods In 967 consecutive patients with acute myocardial infarction who were treated within 6 hours of symptoms, we analyzed the prognostic power of resolution of chest pain and ST-segment elevation >50% at 90 minutes, abrupt creatine kinase rise before 12 hours, and T-wave inversion in infarct-related electrocardiographic leads within the first 24 hours after thrombolysis.
dc.description.abstractResults Global in-hospital mortality rate was 12.0%. Each reperfusion marker was associated with improved outcome. Multivariate logistic regression analysis showed that 3 of the 4 markers of coronary artery reperfusion were significantly and independently associated to low in-hospital mortality rate. The presence of early T-wave inversion was associated with the lowest in-hospital mortality rate (odds ratio 0.25, confidence interval 0.10-0.56). When all markers of coronary artery reperfusion were included in the regression model, T-wave inversion (odds ratio 0.29, confidence interval 0.11-0.68) and abrupt creatine kinase rise (odds ratio 0.36, confidence interval 0.16-0.77) continued to be significantly associated with better outcome.
dc.description.abstractConclusion A systemic analysis of noninvasive markers of coronary artery reperfusion can provide the clinician with on excellent tool to predict clinical outcomes when treating myocardial infarction.
dc.fuente.origenWOS
dc.identifier.issn0002-8703
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97166
dc.identifier.wosidWOS:000082401900024
dc.issue.numero3
dc.language.isoen
dc.pagina.final539
dc.pagina.inicio533
dc.revistaAmerican heart journal
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBedside markers of coronary artery patency and short-term prognosis of patients with acute myocardial infarction and thrombolysis
dc.typeartículo
dc.volumen138
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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