Factors That Affect Concentrations of Cyclosporine During the Induction Period of Kidney Transplantation: Multivariate Analysis

Simple item page
dc.contributor.authorTroncoso, P.
dc.contributor.authorOrtiz, A. M.
dc.contributor.authorVilches, S.
dc.date.accessioned2024-01-10T12:38:57Z
dc.date.available2024-01-10T12:38:57Z
dc.date.issued2011
dc.description.abstractObjective. The pharmacokinetics of cyclosporine (CsA) depend on numerous factors over the transplantation course. The aim of this study was to evaluate the impact of several clinical variables on CsA concentrations during the induction period after kidney transplantation.
dc.description.abstractMethods. Potential variables were contrasted with CsA concentrations at 2 hours postdose (C-2) and with the area under the concentration curve of CsA (AUC) at days 3 and 10 after transplantation. Evaluated variables were: recipient age, gender, body mass index (BMI), type/duration of previous dialysis, pretransplant serum creatinine (sCr), donor type, CsA dose, cold ischemia time, reduction of sCr, and use of other immunosuppressive drugs.
dc.description.abstractResults. This series included 112 patients who displayed an average age of 43 13 years, including 62 men and 31 recipients of living donor organs. The induction dose of CsA was 8.36 +/- 1.53 mg/kg. On day 3, the C-2 was related to the reduction of sCr (P = 0.034) and to the BMI (P = 0.033). There was an inverse correlation with pretransplant sCr (P = 0.012). The AUC correlated with BMI (P = 0.027) and living donor category (P = .002). Patients receiving rapamycin or a locally procured kidney showed a trend toward higher AUC values. On day 10, the CsA dose and use of rapamycin showed a trend to higher values of C-2; the AUC was related to the CsA dose (P = .034). None of the other variables showed significant effects. Analysis between variables showed that time on dialysis correlated with the pretransplant sCr (P = .002) and that the CsA dose was negatively associated with BMI (P = .009).
dc.description.abstractConclusion. Pretransplant sCr, BMI, living donor kidney category, better functional recovery, and the dose of CsA were predictors of CsA concentrations of clinical interest during this induction period. The effect of BMI was not related to higher doses of CsA.
dc.fechaingreso.objetodigital11-04-2024
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.transproceed.2011.06.008
dc.identifier.eissn1873-2623
dc.identifier.issn0041-1345
dc.identifier.pubmedidMEDLINE:21839257
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2011.06.008
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77124
dc.identifier.wosidWOS:000294102000046
dc.information.autorucMedicina;Vilches S ;S/I;62136
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final2294
dc.pagina.inicio2291
dc.publisherELSEVIER SCIENCE INC
dc.revistaTRANSPLANTATION PROCEEDINGS
dc.rightsacceso restringido
dc.subjectCHRONIC-RENAL-FAILURE
dc.subjectMYCOPHENOLIC-ACID
dc.subjectBLOOD-LEVELS
dc.subjectPHARMACOKINETICS
dc.subjectORGAN
dc.subjectABSORPTION
dc.subjectEXPOSURE
dc.subjectGUT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFactors That Affect Concentrations of Cyclosporine During the Induction Period of Kidney Transplantation: Multivariate Analysis
dc.typeartículo
dc.volumen43
sipa.codpersvinculados62136
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-04-11. Factors That Affect Concentrations of Cyclosporine During the Induction Period of Kidney Transplantation - Multivariate Analysis.pdf
Size:
3.29 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas