AXONS GROW IN THE AGING RAT BUT FAST TRANSPORT AND ACETYLCHOLINESTERASE CONTENT REMAIN UNCHANGED

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dc.contributor.authorINESTROSA, NC
dc.contributor.authorALVAREZ, J
dc.date.accessioned2025-01-23T19:25:00Z
dc.date.available2025-01-23T19:25:00Z
dc.date.issued1988
dc.description.abstractCaliber and microtubular density of myelinated fibers, acetylcholinesterase (AChE) content and its accumulation at a ligature were studied in the phrenic nerve of mature (3-4 months) and aging (2-year-old) rats. The number of axons remained constant. The cross-sectional area of the nerve was 67% greater in the older group: the axoplasm, though, constituted about 20% of the nerve tissue irrespective of age. The mean cross-sectional area of myelinated axons was twice as big in aging compared to mature rats. All axons grew in the same proportion irrespective of their original caliber. The microtubular density of 3-.mu.m axons was about 22 microtubules .mu.m2 in mature and aging rats. The AChE activity of aging rats was half as much as that of mature rats if it was expressed per wet weight of nerve tissue but did not change if it was expressed per nerve fiber. Twenty-four hours after ligation of the nerve, total AChE activity rose in mature and aging rats by ca. 168%: the molecular forms.sbd.asymmetric and globular.sbd.accumulated in the same proportion in both age groups. We conclude that myelinated axons grow in the adult stage of life but the structure of axoplasm, content of AChE per axon, and rate of fast transport remain lifelong features of nerve fibers.
dc.fuente.origenWOS
dc.identifier.eissn1872-6240
dc.identifier.issn0006-8993
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99427
dc.identifier.wosidWOS:A1988M418500036
dc.issue.numero1-2
dc.language.isoen
dc.pagina.final338
dc.pagina.inicio331
dc.revistaBrain research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAXONS GROW IN THE AGING RAT BUT FAST TRANSPORT AND ACETYLCHOLINESTERASE CONTENT REMAIN UNCHANGED
dc.typeartículo
dc.volumen441
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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