How viscous is the beating heart? Insights from a computational study

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dc.contributor.authorTikenogullari, Oguz Ziya
dc.contributor.authorCostabal, Francisco Sahli
dc.contributor.authorYao, Jiang
dc.contributor.authorMarsden, Alison
dc.contributor.authorKuhl, Ellen
dc.date.accessioned2025-01-20T21:07:15Z
dc.date.available2025-01-20T21:07:15Z
dc.date.issued2022
dc.description.abstractUnderstanding tissue rheology is critical to accurately model the human heart. While the elastic properties of cardiac tissue have been extensively studied, its viscous properties remain an issue of ongoing debate. Here we adopt a viscoelastic version of the classical Holzapfel Ogden model to study the viscous timescales of human cardiac tissue. We perform a series of simulations and explore stress-relaxation curves, pressure-volume loops, strain profiles, and ventricular wall strains for varying viscosity parameters. We show that the time window for model calibration strongly influences the parameter identification. Using a four-chamber human heart model, we observe that, during the physiologically relevant time scales of the cardiac cycle, viscous relaxation has a negligible effect on the overall behavior of the heart. While viscosity could have important consequences in pathological conditions with compromised contraction or relaxation properties, we conclude that, for simulations within the physiological range of a human heart beat, we can reasonably approximate the human heart as hyperelastic.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00466-022-02180-z
dc.identifier.eissn1432-0924
dc.identifier.issn0178-7675
dc.identifier.urihttps://doi.org/10.1007/s00466-022-02180-z
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93402
dc.identifier.wosidWOS:000799405900001
dc.issue.numero3
dc.language.isoen
dc.pagina.final579
dc.pagina.inicio565
dc.revistaComputational mechanics
dc.rightsacceso restringido
dc.subjectCardiac mechanics
dc.subjectHuman heart
dc.subjectMyocardium
dc.subjectViscoelasticity
dc.subjectFinite element method
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHow viscous is the beating heart? Insights from a computational study
dc.typeartículo
dc.volumen70
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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