Sympathetic and electrochemical skin responses in the assessment of sudomotor function: a comparative study

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dc.contributor.authorIdiaquez, Juan
dc.contributor.authorCasar, Juan Carlos
dc.contributor.authorFadic, Ricardo
dc.contributor.authorIturriaga, Rodrigo
dc.date.accessioned2025-01-20T20:18:23Z
dc.date.available2025-01-20T20:18:23Z
dc.date.issued2023
dc.description.abstractObjectives: The sympathetic skin response (SSR) is a well-established test, whereas the electro-chemical skin conductance (ESC) is still under evaluation. Our aim was therefore to assess the diagnostic accuracy of ESC to detect abnormal sudomotor function, using SSR as a reference test.Methods: A cross sectional observational study was performed of 61 neurological patients assessed for possible sudomotor dysfunction and 50 age-matched healthy controls (HC). Patients with diagnoses of vasovagal syncope (VVS, n=25), Parkinson's disease (PD, n=15), multiple system atrophy (MSA, n=11) and peripheral neuropathies (PN, n=10) were included. Sudomotor function was assessed with SSR and ESC tests in all participants. The absence of SSR in the palms or soles indicates abnormal sudomotor function. Receiver operating characteristic (ROC) analysis was used to assess the diagnostic value of the ESC. Cardiovascular autonomic (CV-Aut) function was evaluated through the Ewing score, based on the following tests: Heart rate change with deep breathing, Valsalva ratio, 30:15 ratio, blood pressure changes on standing and during isometric exercise. A Ewing score > 2 indicates the presence of CV-Aut dysfunction.Results: Mean SSR amplitudes and ESC values showed differences between HC and patients with MSA or PN (p < 0.05), but not in patients with VVS or PD. Absence of SSR was associated with abnormal ESC (p < 0.05). Patients with abnormal CV-Aut dysfunction had lower ESC (p< 0.05). Palm ESC (P-ESC) and sole ESC (S-ESC) assessment had a sensitivity of 0.91 and 0.95 to predict sudomotor dysfunction, with a specificity of 0.78 and 0.85, respectively. The area under ROC curve was 0.905 and 0.98, respectively.Conclusions: ESC in palms and soles has a high diagnostic accuracy for sudomotor dysfunction as detected by absent SSR in patients with MSA and PN. (c) 2022 Elsevier Masson SAS. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.neucli.2022.102840
dc.identifier.eissn1769-7131
dc.identifier.issn0987-7053
dc.identifier.urihttps://doi.org/10.1016/j.neucli.2022.102840
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92459
dc.identifier.wosidWOS:000926652500001
dc.issue.numero2
dc.language.isoen
dc.revistaNeurophysiologie clinique-clinical neurophysiology
dc.rightsacceso restringido
dc.subjectElectrochemical skin
dc.subjectSudomotor
dc.subjectSudoscan
dc.subjectSympathetic skin
dc.subjectresponse
dc.subjectconductance
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSympathetic and electrochemical skin responses in the assessment of sudomotor function: a comparative study
dc.typeartículo
dc.volumen53
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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