DEVELOPMENT AND ASSESSMENT OF SPECTROSCOPY METHODOLOGIES AND CHEMOMETRICS STRATEGIES TO DETECT PHARMACEUTICALS BLEND ENDPOINT IN A PHARMACEUTICAL POWDER BLEND

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dc.contributor.authorPino Torres, Cesar
dc.contributor.authorCastillo Felices, Rosario
dc.contributor.authorMundaca Uribe, Rodolfo
dc.contributor.authorMendeZ Herrera, Paola
dc.contributor.authorAranda Bustos, Mario
dc.contributor.authorPena Farfal, Carlos
dc.date.accessioned2024-01-10T14:23:03Z
dc.date.available2024-01-10T14:23:03Z
dc.date.issued2021
dc.description.abstractManufacturing pharmaceutical products is one of the most regulated industrial processes due to the importance of its effects on human health. These processes require many physical and chemical determinations through chromatographic techniques coupled with different detectors. However, the pharmaceutical industry is not considering the growth that spectroscopic techniques have had in these fields of application, especially to monitor the blending process.
dc.description.abstractThis study evaluates different sampling methods for pharmaceutical blending processes by near-infrared spectroscopy (NIRS) and Vis-NIR spectroscopy. The pharmaceutical mixture consisted of three active ingredients at different concentrations. Various qualitative and quantitative strategies were used to evaluate the endpoint of the blending process. The results revealed the feasibility of different spectral analyses to establish the homogeneity of the mixture, which may be especially useful for applications at the industrial level in routine analysis or as a first choice. HPLC confirmed the final blend.
dc.description.funderVicerrectoria de Investigacion y Doctorados Universidad Autonoma de Chile
dc.description.funderANIDChile
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.issn0717-9707
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80038
dc.identifier.wosidWOS:000756195600005
dc.information.autorucFacultad de Química y de Farmacia; Aranda Bustos, Mario Antonio; S/I; 1103178
dc.issue.numero4
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final5397
dc.pagina.inicio5387
dc.publisherSOC CHILENA QUIMICA
dc.revistaJOURNAL OF THE CHILEAN CHEMICAL SOCIETY
dc.rightsregistro bibliográfico
dc.subjectCaffeine
dc.subjectAcetylsalicylic acid
dc.subjectParacetamol
dc.subjectNIR
dc.subjectpharmaceutical analysis
dc.subjectNEAR-INFRARED SPECTROSCOPY
dc.subjectVARIOGRAPHIC ANALYSIS
dc.subjectAUTOMATED-SYSTEM
dc.subjectNIR
dc.subject.ods02 Zero Hunger
dc.subject.odspa02 Hambre cero
dc.titleDEVELOPMENT AND ASSESSMENT OF SPECTROSCOPY METHODOLOGIES AND CHEMOMETRICS STRATEGIES TO DETECT PHARMACEUTICALS BLEND ENDPOINT IN A PHARMACEUTICAL POWDER BLEND
dc.typeartículo
dc.volumen66
sipa.codpersvinculados1103178
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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