Shortcomings, limitations and gaps in physiological roles of extracellular vesicles in obesity

Simple item page
dc.contributor.authorValero, Paola
dc.contributor.authorSilva, Katherin
dc.contributor.authorValenzuela-Hinrichsen, Andres
dc.contributor.authorVasquez, Antonia
dc.contributor.authorEspinoza, Fernanda
dc.contributor.authorLira, Fernanda
dc.contributor.authorCornejo, Marcelo
dc.contributor.authorFuentes, Gonzalo
dc.contributor.authorGonzalez, Daniel
dc.contributor.authorMoore-Carrasco, Rodrigo
dc.contributor.authorvan der Beek, Eline M.
dc.contributor.authorHillebrands, Jan-Luuk
dc.contributor.authorvan Goor, Harry
dc.contributor.authorGrismaldo, Adriana
dc.contributor.authorSobrevia, Luis
dc.date.accessioned2025-01-20T16:04:55Z
dc.date.available2025-01-20T16:04:55Z
dc.date.issued2024
dc.description.abstractExtracellular vesicles (EVs) play a crucial role in mediating communication between cells across species and kingdoms. The intercellular communication facilitated by EVs through autocrine and paracrine signalling mechanisms is essential for cell survival, maintaining normal metabolic functions and ensuring overall bodily homeostasis and health. Extracellular vesicles are present in various bodily fluids, such as pleural effusions, plasma, breast milk, amniotic fluid, semen and saliva. Additionally, the generation and release of EVs contribute to the removal of cellular waste. Patients with obesity exhibit a higher release and amount of circulating EVs than individuals with normal weight. This increased EV release in obesity might contribute to the inflammatory state characteristic of this metabolic condition, because higher levels of pro-inflammatory molecules are found within their cargo. However, interpreting results related to EV abundance, cargo and biological actions can be complicated by several factors; these include variations in cell sources, a wide age range (from children to the elderly), a mix of females and males, medication use and health status, a range of body weights (from normal weight to morbid obesity) and differences between in vitro assays using cell lines versus primary cultures. This article addresses the shortcomings, limitations and gaps in knowledge, providing a framework for enhancing our understanding of the physiological effects of EVs on obesity. image
dc.description.funderFaculty of Excellence program, Tecnologico de Monterrey, Mexico
dc.fuente.origenWOS
dc.identifier.doi10.1113/JP286955
dc.identifier.eissn1469-7793
dc.identifier.issn0022-3751
dc.identifier.urihttps://doi.org/10.1113/JP286955
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89855
dc.identifier.wosidWOS:001344130300001
dc.language.isoen
dc.revistaJournal of physiology-london
dc.rightsacceso restringido
dc.subjectage
dc.subjectexosomes
dc.subjectextracellular vesicles
dc.subjecthuman
dc.subjectobesity
dc.subjectsex
dc.titleShortcomings, limitations and gaps in physiological roles of extracellular vesicles in obesity
dc.typeartículo
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas