EARLY STAGES OF GALLSTONE FORMATION IN GUINEA-PIG ARE ASSOCIATED WITH DECREASED BILIARY SENSITIVITY TO CHOLECYSTOKININ

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dc.contributor.authorPOSTON, GJ
dc.contributor.authorSINGH, P
dc.contributor.authorDRAVIAM, E
dc.contributor.authorYAO, CZ
dc.contributor.authorGOMEZ, G
dc.contributor.authorTHOMPSON, JC
dc.date.accessioned2025-01-23T19:22:04Z
dc.date.available2025-01-23T19:22:04Z
dc.date.issued1992
dc.description.abstractThe purpose of this study was to measure differences in gallbladder sensitivity to cholecystokinin (CCK) in vivo during the early stages of gallstone formation and to correlate these findings to gallbladder CCK receptors. Guinea pigs were placed on either a normal diet or a two-week cholelithogenic diet, after which gallbladder emptying pressure to exogenously administered CCK was measured in vivo. according to the presence or absence of gallstones. At all doses of CCK tested (except 10(-10) mol/kg), the gallbladder response to CCK of guinea pigs that did not develop gallstones (on the cholelithogenic diet) was more sensitive than that of guinea pigs that did develop gallstones. Neither group was different from guinea pigs on a normal diet. In a second experiment, CCK receptors were measured on gallbladder muscularis from guinea pigs after two weeks on the same diet as in the first experiment. Those guinea pigs that did not develop gallstones had greater concentrations of CCK receptors (149 +/- 9 fmol/mg protein) than those that did develop gallstones (70 +/- 23 fmol/mg protein). Neither group was different from normal diet guinea pigs (119 +/- 57 fmol/mg protein). At the time point measured, there were no differences in the lipid chemistry or protein concentrations of gallbladder bile between the guinea pigs on the cholelithogenic diet that did or did not develop gallstones, or those on normal guinea pig chow. We conclude that the early stages of gallstone formation in guinea pigs are associated with decreased gallbladder sensitivity to CCK and that this change may be due to a lower concentration of CCK receptors on the gallbladder smooth muscle.
dc.fuente.origenWOS
dc.identifier.issn0163-2116
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98951
dc.identifier.wosidWOS:A1992JH80700013
dc.issue.numero8
dc.language.isoen
dc.pagina.final1244
dc.pagina.inicio1236
dc.revistaDigestive diseases and sciences
dc.rightsacceso restringido
dc.subjectCHOLECYSTOKININ
dc.subjectGALLBLADDER
dc.subjectGALLSTONES
dc.subjectCHOLECYSTOKININ RECEPTORS
dc.subjectBILIARY MOTILITY
dc.subjectGUINEA PIG
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEARLY STAGES OF GALLSTONE FORMATION IN GUINEA-PIG ARE ASSOCIATED WITH DECREASED BILIARY SENSITIVITY TO CHOLECYSTOKININ
dc.typeartículo
dc.volumen37
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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