Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multinational cohort

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dc.contributor.authorPapadopoulos, Nikolaos G.
dc.contributor.authorMathioudakis, Alexander G.
dc.contributor.authorCustovic, Adnan
dc.contributor.authorDeschildre, Antoine
dc.contributor.authorPhipatanakul, Wanda
dc.contributor.authorWong, Gary
dc.contributor.authorXepapadaki, Paraskevi
dc.contributor.authorAbou-Taam, Rola
dc.contributor.authorAgache, Ioana
dc.contributor.authorCastro-Rodriguez, Jose A.
dc.contributor.authorChen, Zhimin
dc.contributor.authorCros, Pierrick
dc.contributor.authorDubus, Jean-Christophe
dc.contributor.authorEl-Sayed, Zeinab Awad
dc.contributor.authorEl-Owaidy, Rasha
dc.contributor.authorFeleszko, Wojciech
dc.contributor.authorFierro, Vincenzo
dc.contributor.authorFiocchi, Alessandro
dc.contributor.authorGarcia-Marcos, Luis
dc.contributor.authorGoh, Anne
dc.contributor.authorHossny, Elham M.
dc.contributor.authorHuerta Villalobos, Yunuen R.
dc.contributor.authorJartti, Tuomas
dc.contributor.authorLe Roux, Pascal
dc.contributor.authorLevina, Julia
dc.contributor.authorLopez Garcia, Aida Ines
dc.contributor.authorRamos, Angel Mazon
dc.contributor.authorMorais-Almeida, Mario
dc.contributor.authorMurray, Clare
dc.contributor.authorNagaraju, Karthik
dc.contributor.authorNagaraju, Major K.
dc.contributor.authorNavarrete Rodriguez, Elsy Maureen
dc.contributor.authorNamazova-Baranova, Leyla
dc.contributor.authorNieto Garcia, Antonio
dc.contributor.authorPozo Beltran, Cesar Fireth
dc.contributor.authorRatchataswan, Thanaporn
dc.contributor.authorRivero Yeverino, Daniela
dc.contributor.authorRodriguez Zagal, Erendira
dc.contributor.authorSchweitzer, Cyril E.
dc.contributor.authorTulkki, Marleena
dc.contributor.authorWasilczuk, Katarzyna
dc.contributor.authorXu, Dan
dc.date.accessioned2025-01-20T23:52:31Z
dc.date.available2025-01-20T23:52:31Z
dc.date.issued2021
dc.description.abstractBackground The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes.
dc.description.abstractMethods The PeARL multinational cohort included 1,054 children with asthma and 505 non-asthmatic children aged between 4 and 18 years from 25 pediatric departments, from 15 countries globally. We compared the frequency of acute respiratory and febrile presentations during the first wave of the COVID-19 pandemic between groups and with data available from the previous year. In children with asthma, we also compared current and historical disease control.
dc.description.abstractResults During the pandemic, children with asthma experienced fewer upper respiratory tract infections, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks, and hospitalizations due to asthma, in comparison with the preceding year. Sixty-six percent of asthmatic children had improved asthma control while in 33% the improvement exceeded the minimal clinically important difference. Pre-bronchodilatation FEV1 and peak expiratory flow rate were improved during the pandemic. When compared to non-asthmatic controls, children with asthma were not at increased risk of LRTIs, episodes of pyrexia, emergency visits, or hospitalizations during the pandemic. However, an increased risk of URTIs emerged.
dc.description.abstractConclusion Childhood asthma outcomes, including control, were improved during the first wave of the COVID-19 pandemic, probably because of reduced exposure to asthma triggers and increased treatment adherence. The decreased frequency of acute episodes does not support the notion that childhood asthma may be a risk factor for COVID-19. Furthermore, the potential for improving childhood asthma outcomes through environmental control becomes apparent.
dc.fuente.origenWOS
dc.identifier.doi10.1111/all.14787
dc.identifier.eissn1398-9995
dc.identifier.issn0105-4538
dc.identifier.urihttps://doi.org/10.1111/all.14787
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94914
dc.identifier.wosidWOS:000631960700001
dc.issue.numero6
dc.language.isoen
dc.pagina.final1775
dc.pagina.inicio1765
dc.revistaAllergy
dc.rightsacceso restringido
dc.subjectchildhood asthma
dc.subjectcoronavirus
dc.subjectCOVID-19
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleChildhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multinational cohort
dc.typeartículo
dc.volumen76
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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