Immunization with a Recombinant Bacillus Calmette-Guerin Strain Confers Protective Th1 Immunity against the Human Metapneumovirus

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dc.contributor.authorPalavecino, Christian E.
dc.contributor.authorCespedes, Pablo F.
dc.contributor.authorGomez, Roberto S.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorBueno, Susan M.
dc.date.accessioned2025-01-23T21:48:37Z
dc.date.available2025-01-23T21:48:37Z
dc.date.issued2014
dc.description.abstractAlong with the human respiratory syncytial virus (hRSV), the human metapneumovirus (hMPV) is one of the leading causes of childhood hospitalization and a major health burden worldwide. Unfortunately, owing to an inefficient immunological memory, hMPV infection provides limited immune protection against reinfection. Furthermore, hMPV can induce an inadequate Th2 type immune response that causes severe lung inflammation, leading to airway obstruction. Similar to hRSV, it is likely that an effective clearance of hMPV would require a balanced Th1 type immunity by the host, involving the activation of IFN-gamma-secreting T cells. A recognized inducer of Th1 immunity is Mycobacterium bovis bacillus Calmette-Guerin (BCG), which has been used in newborns for many decades and in several countries as a tuberculosis vaccine. We have previously shown that immunization with BCG strains expressing hRSV Ags can induce an efficient immune response that protects against this virus. In this study, we show that immunization with rBCG strains expressing the phosphoprotein from hMPV also can induce protective Th1 immunity. Mice immunized with rBCG were protected against weight loss, airway inflammation, and viral replication in the lungs after hMPV infection. Our rBCG vaccine also induced the activation of hMPV-specific T cells producing IFN-gamma and IL-2, which could protect from hMPV infection when transferred to recipient mice. These data strongly support the notion that rBCG induces protective Th1 immunity and could be considered as an efficient vaccine against hMPV.
dc.fuente.origenWOS
dc.identifier.doi10.4049/jimmunol.1300118
dc.identifier.eissn1550-6606
dc.identifier.issn0022-1767
dc.identifier.urihttps://doi.org/10.4049/jimmunol.1300118
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101761
dc.identifier.wosidWOS:000328950700023
dc.issue.numero1
dc.language.isoen
dc.pagina.final223
dc.pagina.inicio214
dc.revistaJournal of immunology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImmunization with a Recombinant Bacillus Calmette-Guerin Strain Confers Protective Th1 Immunity against the Human Metapneumovirus
dc.typeartículo
dc.volumen192
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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