ASYMMETRIC DISTRIBUTION OF PURINERGIC AND ADRENERGIC NEUROTRANSMISSION COOPERATES IN THE MOTOR-ACTIVITY ALONG THE RAT VAS-DEFERENS

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dc.contributor.authorROHDE, GC
dc.contributor.authorVENEZIAN, E
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-23T19:26:11Z
dc.date.available2025-01-23T19:26:11Z
dc.date.issued1986
dc.description.abstractThe distribution of purinergic and adrenergic responses in the epididymal and prostatic segment of the rat vas deferens were studied in vitro. Prazosin antagonizes the twitch elicited by electrical stimulation mainly in the epididymal segment while .alpha.,.beta.-methyleneadenosine 5''-triphosphate (.alpha.,.beta.-mATP) preferentially inhibits the response of the prostatic segment. Using both prazosin plus .alpha.,.beta.-mATP, the response to field stimulation was completely inhibited. Concentration response curves revealed that adrenergic compounds elicited a greater contraction in the epididymal portion than in the prostatic end of the ductus. Purinergic compounds caused a contraction of greater magnitude in the prostatic portion. The results suggest that adrenergic and purinergic mechanisms are asymmetrically distributed along the vas deferens reflecting a gradient of adrenergic and purinergic receptors along the ductus.
dc.fuente.origenWOS
dc.identifier.eissn1872-7972
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99577
dc.identifier.wosidWOS:A1986E797700014
dc.issue.numero2
dc.language.isoen
dc.pagina.final202
dc.pagina.inicio197
dc.revistaNeuroscience letters
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleASYMMETRIC DISTRIBUTION OF PURINERGIC AND ADRENERGIC NEUROTRANSMISSION COOPERATES IN THE MOTOR-ACTIVITY ALONG THE RAT VAS-DEFERENS
dc.typeartículo
dc.volumen71
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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