SNAREs in mammalian sperm: Possible implications for fertilization

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dc.contributor.authorRamalho-Santos, J
dc.contributor.authorMoreno, RD
dc.contributor.authorSutovsky, P
dc.contributor.authorChan, AWS
dc.contributor.authorHewitson, L
dc.contributor.authorWessel, GM
dc.contributor.authorSimerly, CR
dc.contributor.authorSchatten, G
dc.date.accessioned2025-01-21T01:31:17Z
dc.date.available2025-01-21T01:31:17Z
dc.date.issued2000
dc.description.abstractSoluble N-ethylmalameide-sensitive factor attachment protein receptor (SNARE) proteins are present in mammalian sperm and could be involved in critical membrane fusion events during fertilization, namely the acrosome reaction. Vesicle-associated membrane protein/synaptobrevin, a SNARE on the membrane of a vesicular carrier, and syntaxin 1, a SNARE on the target membrane, as well as the calcium sensor synaptotagmin I, are present in the acrosome of mammalian sperm (human, rhesus monkey, bull, hamster, mouse). Sperm SNAREs are sloughed off during the acrosome reaction, paralleling the release of sperm membrane vesicles and acrosomal contents, and SNARE antibodies inhibit both the acrosome reaction and fertilization, without inhibiting sperm-egg binding. In addition, sperm SNAREs may be responsible, together with other sperm components, for the asynchronous male DNA decondensation that occurs following intracytoplasmic sperm injection, an assisted reproduction technique that bypasses normal sperm-egg surface interactions. The results suggest the participation of sperm SNAREs during membrane fusion events at fertilization in mammals. (C) 2000 Academic Press.
dc.fuente.origenWOS
dc.identifier.doi10.1006/dbio.2000.9745
dc.identifier.eissn1095-564X
dc.identifier.issn0012-1606
dc.identifier.urihttps://doi.org/10.1006/dbio.2000.9745
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97029
dc.identifier.wosidWOS:000088060400005
dc.issue.numero1
dc.language.isoen
dc.pagina.final69
dc.pagina.inicio54
dc.revistaDevelopmental biology
dc.rightsacceso restringido
dc.subjectsperm
dc.subjectfertilization
dc.subjectmembrane
dc.subjectexocytosis
dc.subjectacrosome
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSNAREs in mammalian sperm: Possible implications for fertilization
dc.typeartículo
dc.volumen223
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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