Expression of the nucleoside transporters hENT1 (SLC29) and hCNT1 (SLC28) in pediatric acute myeloid leukemia

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dc.contributor.authorJaramillo, Adrian Christopher
dc.contributor.authorHubeek, Isabelle
dc.contributor.authorBroekhuizen, Richard
dc.contributor.authorPastor-Anglada, Marcal
dc.contributor.authorKaspers, Gertjan J. L.
dc.contributor.authorJansen, Gerrit
dc.contributor.authorCloos, Jacqueline
dc.contributor.authorPeters, Godefridus J.
dc.date.accessioned2025-01-23T19:52:14Z
dc.date.available2025-01-23T19:52:14Z
dc.date.issued2020
dc.description.abstractCellular uptake of clinically important deoxynucleoside analogs is mediated by nucleoside transporters including the human equilibrative nucleoside transporter 1 (hENT1) and the concentrative nucleoside transporter-1 (hCNT1). These transporters are responsible for influx of cytarabine and reduced hENT1 expression is a major resistance mechanism in acute myeloid leukemia. We determined hENT1 and hCNT1 protein expression by immunocytochemistry in 50 diagnostic pediatric acute myeloid leukemia patient samples. All samples expressed hENT1 [9/43 (21%) low; 26/43 (60%) medium and 8/43 (19%) high] and hCNT1 [2/42 (5%) low; 35/42 (83%) medium and 5/42 (12%) high] at the cell membrane and cytoplasm. Statistical analysis showed a non-significant relationship between survival and transporter expression and in vitro drug sensitivity. In conclusion, the nucleoside transporters hENT1 and hCNT1 are broadly expressed in pediatric acute myeloid leukemia at diagnosis.
dc.fuente.origenWOS
dc.identifier.doi10.1080/15257770.2020.1746803
dc.identifier.eissn1532-2335
dc.identifier.issn1525-7770
dc.identifier.urihttps://doi.org/10.1080/15257770.2020.1746803
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100624
dc.identifier.wosidWOS:000527598200001
dc.issue.numero10-12
dc.language.isoen
dc.pagina.final1388
dc.pagina.inicio1379
dc.revistaNucleosides nucleotides & nucleic acids
dc.rightsacceso restringido
dc.subjectAcute myeloid leukemia (AML)
dc.subjectacute lymphoblastic leukemia (ALL)
dc.subjecthuman equilibrative nucleoside transporter-1 (hENT1)
dc.subjecthuman concentrative nucleoside transporter-1 (hCNT1)
dc.subjectdeoxynucleoside analogs (NAs)
dc.subjectcytarabine (Ara-C)
dc.subjectbovine serum albumin (BSA)
dc.subjectphosphate buffered saline (PBS)
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExpression of the nucleoside transporters hENT1 (SLC29) and hCNT1 (SLC28) in pediatric acute myeloid leukemia
dc.typeartículo
dc.volumen39
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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