Thromboprophylaxis in major knee and hip replacement surgery: a review

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dc.contributor.authorEymin, Gonzalo
dc.contributor.authorJaffer, Amir K.
dc.date.accessioned2024-01-10T14:22:13Z
dc.date.available2024-01-10T14:22:13Z
dc.date.issued2012
dc.description.abstractPatients undergoing total knee and total hip replacement (THR/TKR) surgery are at high risk of venous thromboembolism (VTE), and routine thromboprophylaxis is recommended after these procedures. However, current thromboprophylaxis may require daily injections, careful anticoagulation monitoring, and dietary restrictions, which can lead to poor patient compliance and suboptimal outcomes. Therefore, there is an unmet need for simpler medication options. Newer oral anticoagulants have improved efficacy over standard treatments, with convenient dosing regimens, more predictable pharmacologic profiles that reduce the need for anticoagulation monitoring, and fewer drug or food interactions. These drugs have the potential to simplify anticoagulation after THR or TKR surgery, which may lead to improved adherence, thus lowering the incidence of VTE and associated complications after surgery.
dc.description.funderJanssen Scientific Affairs, LLC
dc.description.funderNHLBI
dc.description.funderAstra Zeneca
dc.fechaingreso.objetodigital2024-03-13
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s11239-012-0751-5
dc.identifier.eissn1573-742X
dc.identifier.issn0929-5305
dc.identifier.pubmedidMEDLINE:22653706
dc.identifier.urihttps://doi.org/10.1007/s11239-012-0751-5
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79887
dc.identifier.wosidWOS:000309940900013
dc.information.autorucMedicina;Eymin G;S/I;9107
dc.issue.numero4
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final525
dc.pagina.inicio518
dc.publisherSPRINGER
dc.revistaJOURNAL OF THROMBOSIS AND THROMBOLYSIS
dc.rightsacceso restringido
dc.subjectAnticoagulation
dc.subjectProphylaxis
dc.subjectVenous thromboembolism
dc.subjectTotal hip replacement
dc.subjectTotal knee replacement
dc.subjectHEPARIN-INDUCED THROMBOCYTOPENIA
dc.subjectMOLECULAR-WEIGHT HEPARIN
dc.subjectRANDOMIZED DOUBLE-BLIND
dc.subjectDEEP-VEIN THROMBOSIS
dc.subjectFACTOR XA INHIBITORS
dc.subjectVENOUS THROMBOEMBOLISM
dc.subjectDABIGATRAN ETEXILATE
dc.subjectMEDICAL PATIENTS
dc.subjectENOXAPARIN
dc.subjectARTHROPLASTY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThromboprophylaxis in major knee and hip replacement surgery: a review
dc.typeartículo
dc.volumen34
sipa.codpersvinculados9107
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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