Increase of Bone Resorption and the Parathyroid Hormone in Postmenopausal Women in the Long-term after Roux-en-Y Gastric Bypass

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dc.contributor.authorValderas, Juan P.
dc.contributor.authorVelasco, Soledad
dc.contributor.authorSolari, Sandra
dc.contributor.authorLiberona, Yessica
dc.contributor.authorViviani, Paola
dc.contributor.authorMaiz, Alberto
dc.contributor.authorEscalona, Alex
dc.contributor.authorGonzalez, Gilberto
dc.date.accessioned2025-01-21T00:08:27Z
dc.date.available2025-01-21T00:08:27Z
dc.date.issued2009
dc.description.abstractThe effects of Roux-en-Y Gastric Bypass (RYGB) on bone in the long-term remains unclear. We assessed bone metabolism and bone mineral density (BMD) 1 to 5 years after RYGB.
dc.description.abstractWe designed a retrospective cohort study in 26 postmenopausal women (58.0 +/- 3.9 years old) with RYGB 3.5 +/- 1.1 years before (body mass index (BMI) 29.5 +/- 3.8 kg/m(2), presurgery 43.6 +/- 5.5 kg/m(2)) and 26 nonoperated women (57.5 +/- 4.7 years old, BMI 29.2 +/- 4.1 kg/m(2)) matched by age and BMI. The main measures were BMD, serum carboxy telopeptide (CTx), total alkaline phosphatases (ALP), parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), and ghrelin.
dc.description.abstractRYGB group, compared to nonoperated women, had higher CTx (0.71 +/- 0.21 vs. 0.43 +/- 0.15 ng/ml; P < 0.01) and PTH (68.3 +/- 35 vs. 49.4 +/- 16 pg/ml; P = 0.02). There were no differences between RYGB and nonoperated women in: calcium and vitamin D intake (759 +/- 457 vs. 705 +/- 460 mg/day; 176 +/- 160 vs. 111 +/- 86 UI/day), ghrelin (763 +/- 336 vs. 621 +/- 274 pg/ml), ALP (101 +/- 22 vs. 94 +/- 25 UI/l), 25OHD (18.8 +/- 7.6 vs. 17.4 +/- 5.9 ng/ml), lumbar spine BMD (1.059 +/- 0.32 vs. 1.071 +/- 0.207 g/cm(2)), or femoral neck BMD (0.892 +/- 0.109 vs. 0.934 +/- 1.1 g/cm(2)).
dc.description.abstractRYGB is associated to high bone resorption and hyperparathyroidism prevalence in postmenopausal women in the long-term. This occurs independently of the intake of calcium, vitamin D status, or ghrelin and does not seem to affect BMD after RYGB.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s11695-009-9890-y
dc.identifier.eissn1708-0428
dc.identifier.issn0960-8923
dc.identifier.urihttps://doi.org/10.1007/s11695-009-9890-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95670
dc.identifier.wosidWOS:000268120600489
dc.issue.numero8
dc.language.isoen
dc.pagina.final1138
dc.pagina.inicio1132
dc.revistaObesity surgery
dc.rightsacceso restringido
dc.subjectBariatric surgery
dc.subjectGastric bypass
dc.subjectHyperparathyroidism
dc.subjectBone
dc.subjectObesity
dc.subjectMenopause
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIncrease of Bone Resorption and the Parathyroid Hormone in Postmenopausal Women in the Long-term after Roux-en-Y Gastric Bypass
dc.typeartículo
dc.volumen19
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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