Clinical Outcomes of Children Meeting the At-Risk for PARDS Criteria Before PICU Admission: A Single-Center Study

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dc.article.numbere71146
dc.catalogadoryvc
dc.contributor.authorBustos Gajardo, F. D.
dc.contributor.authorJeria, R. A.
dc.contributor.authorPiraino, T.
dc.contributor.authorCruces, P.
dc.contributor.authorDamiani Rebolledo, L. Felipe
dc.date.accessioned2025-06-25T22:28:19Z
dc.date.available2025-06-25T22:28:19Z
dc.date.issued2025
dc.description.abstractObjective: To evaluate the ability of the criteria “At-risk for PARDS” to identify patients with acute respiratory infection hospitalized outside the pediatric intensive care unit (PICU) who are at high risk of developing pediatric acute respiratory distress syndrome (PARDS) and describe the timing for the identification. The secondary aim was to explore clinical outcome differences between patients with and without risk for PARDS. Methods: We conducted an observational prospective cohort study from June to August 2019. Children under 15 years old hospitalized in a pediatric ward due to an acute respiratory tract infection were included. Main Results: A total of 177 patients with a median age of 12 (IQR 5; 25) months were included. Registered data included demographics, respiratory support, at-risk for PARDS and PARDS diagnosis according to PALICC consensus. PICU admission, hospital length of stay (LOS) and intrahospital mortality were the outcomes compared between children with and without risk for PARDS. The at-risk criteria, within 48 h of admission, showed an overall accuracy, sensitivity, and specificity of 82.5%, 100%, and 81.9% respectively, to detect patients that progress to PARDS. The at-risk for PARDS criteria was met in 37 cases (20.9%), which also were more likely to developed PARDS (6/37 [16.2%] vs. 0/140 [0%]; p < 0.001), had higher admission to PICU (16/37 [43.2%] vs. 0 [0%]; p < 0.001) and hospital LOS (7 [6; 12] days vs. 5 [3−6] days; p < 0.001), compared with the group without at-risk for PARDS. Conclusions: The at-risk for PARDS criteria within 48 h of admission demonstrated an adequate ability to identify patients with a respiratory infection at increased risk of developing PARDS. Patients who met the at-risk for PARDS criteria before PICU admission presented with unfavorable clinical outcomes compared with those without risk.
dc.description.funderAgencia Nacional de Investigacion y Desarrollo
dc.description.funderFondecyt
dc.description.funderFondecyt
dc.format.extent7 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.1002/ppul.71146
dc.identifier.eissn1099-0496
dc.identifier.issn8755-6863
dc.identifier.scopusidSCOPUS_ID:105006718906
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104762
dc.identifier.wosidWOS:001500894000024
dc.information.autorucDepartamento de Ciencias de la Salud; Damiani Rebolledo, L. Felipe; 0000-0002-8338-0488; 237645
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherJohn Wiley and Sons Inc
dc.revistaPediatric Pulmonology
dc.rightsacceso restringido
dc.subjectAcute respiratory infection
dc.subjectMechanical ventilation
dc.subjectPediatric acute respiratory distress syndrome
dc.subjectPediatric intensive care unit
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical Outcomes of Children Meeting the At-Risk for PARDS Criteria Before PICU Admission: A Single-Center Study
dc.typeartículo
dc.volumen60
sipa.codpersvinculados237645
sipa.trazabilidadSCOPUS;2025-06-15
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