Delta oscillations phase limit neural activity during sevoflurane anesthesia

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dc.contributor.authorChamadia, Shubham
dc.contributor.authorPedemonte, Juan C.
dc.contributor.authorHahm, Eunice Y.
dc.contributor.authorMekonnen, Jennifer
dc.contributor.authorIbala, Reine
dc.contributor.authorGitlin, Jacob
dc.contributor.authorEthridge, Breanna R.
dc.contributor.authorQu, Jason
dc.contributor.authorVazquez, Rafael
dc.contributor.authorRhee, James
dc.contributor.authorLiao, Erika T.
dc.contributor.authorBrown, Emery N.
dc.contributor.authorAkeju, Oluwaseun
dc.date.accessioned2025-01-23T21:09:31Z
dc.date.available2025-01-23T21:09:31Z
dc.date.issued2019
dc.description.abstractUnderstanding anesthetic mechanisms with the goal of producing anesthetic states with limited systemic side effects is a major objective of neuroscience research in anesthesiology. Coherent frontal alpha oscillations have been postulated as a mechanism of sevoflurane general anesthesia. This postulate remains unproven. Therefore, we performed a single-site, randomized, cross-over, high-density electroencephalogram study of sevoflurane and sevoflurane-plus-ketamine general anesthesia in 12 healthy subjects. Data were analyzed with multitaper spectral, global coherence, cross-frequency coupling, and phase-dependent methods. Our results suggest that coherent alpha oscillations are not fundamental for maintaining sevoflurane general anesthesia. Taken together, our results suggest that sub-anesthetic and general anesthetic sevoflurane brain states emerge from impaired information processing instantiated by a delta-higher frequency phase-amplitude coupling syntax. These results provide fundamental new insights into the neural circuit mechanisms of sevoflurane anesthesia and suggest that anesthetic states may be produced by extracranial perturbations that cause delta-higher frequency phase-amplitude interactions.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s42003-019-0664-3
dc.identifier.eissn2399-3642
dc.identifier.urihttps://doi.org/10.1038/s42003-019-0664-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100816
dc.identifier.wosidWOS:000496767800001
dc.language.isoen
dc.revistaCommunications biology
dc.rightsacceso restringido
dc.titleDelta oscillations phase limit neural activity during sevoflurane anesthesia
dc.typeartículo
dc.volumen2
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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