KALLIKREIN EXCRETION - RELATIONSHIP WITH MATURATION AND RENAL-FUNCTION IN HUMAN NEONATES AT DIFFERENT GESTATIONAL AGES

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dc.contributor.authorVIO, CP
dc.contributor.authorOLAVARRIA, F
dc.contributor.authorKRAUSE, S
dc.contributor.authorHERRMANN, F
dc.contributor.authorGROB, K
dc.date.accessioned2025-01-23T19:25:33Z
dc.date.available2025-01-23T19:25:33Z
dc.date.issued1987
dc.description.abstractKallikrein excretion and renal function were studied on 37 one-day-old newborn infants (14 fullterm and 23 preterm infants). Preterm infants excreted less kallikrein (p < 0.001), had lower creatinine clearance (p < 0.02) and urinary osmolality (p < 0.01). They had higher values on urinary volume (p < 0.001), FENa (p < 0.001), FEk (p < 0.02), and free water clearance (p < 0.01) than fullterm infants. The excretion of kallikrein correlated directly with gestational age (p < 0.01) and body weight (p < 0.01). No correlations were found with FENa, urinary volume, FEk or free water clearance. The values of kallikrein excretion were very low when compared with a young adult population. As kallikrein is synthesized in the distal nephron we advance as an hypothesis that the low levels of kallikrein excretion observed in newborns could be a reflection of immature distal tubular mass, and to the relative unresponsiveness of the distal nephron to hormones known to stimulate renal kallikrein such as aldosterone and antidiuretic hormone.
dc.fuente.origenWOS
dc.identifier.issn0006-3126
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99497
dc.identifier.wosidWOS:A1987K055700001
dc.issue.numero3
dc.language.isoen
dc.pagina.final126
dc.pagina.inicio121
dc.revistaBiology of the neonate
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleKALLIKREIN EXCRETION - RELATIONSHIP WITH MATURATION AND RENAL-FUNCTION IN HUMAN NEONATES AT DIFFERENT GESTATIONAL AGES
dc.typeartículo
dc.volumen52
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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