Herbal and Dietary Supplements-Induced Liver Injury in Latin America: Experience From the LATINDILI Network

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dc.contributor.authorBessone, Fernando
dc.contributor.authorGarcia-Cortes, Miren
dc.contributor.authorMedina-Caliz, Inmaculada
dc.contributor.authorHernandez, Nelia
dc.contributor.authorParana, Raymundo
dc.contributor.authorMendizabal, Manuel
dc.contributor.authorSchinoni, Maria, I
dc.contributor.authorRidruejo, Ezequiel
dc.contributor.authorNunes, Vinicius
dc.contributor.authorPeralta, Mirta
dc.contributor.authorSantos, Genario
dc.contributor.authorAnders, Margarita
dc.contributor.authorChiodi, Daniela
dc.contributor.authorTagle, Martin
dc.contributor.authorMontes, Pedro
dc.contributor.authorCarrera, Enrique
dc.contributor.authorArrese, Marco
dc.contributor.authorIsabel Lizarzabal, M.
dc.contributor.authorAlvarez-Alvarez, Ismael
dc.contributor.authorCaballano-Infantes, Estefania
dc.contributor.authorNiu, Hao
dc.contributor.authorPinazo, Jose
dc.contributor.authorCabello, Maria R.
dc.contributor.authorIsabel Lucena, M.
dc.contributor.authorAndrade, Raul J.
dc.date.accessioned2025-01-20T21:13:02Z
dc.date.available2025-01-20T21:13:02Z
dc.date.issued2022
dc.description.abstractBACKGROUND: Herbal and dietary supplements (HDS) consumption, a growing cause of hepatotoxicity, is a common practice among Latin-American populations. Objectives: To evaluate clinical, laboratory features and outcome in HDS-hepatotoxicity included in the Latin America-Drug Induced Liver Injury (LATINDILI) Network.
dc.description.abstractMETHODS: A total of 29 adjudicated cases of HDS hepatotoxicity reported to the LATINDILI Network from October 2011 through December 2019 were compared with 322 DILI cases due to conventional drugs and 16 due to anabolic steroids as well as with other series of HDS-hepatotoxicity.
dc.description.abstractRESULTS: From 367 DILI cases, 8% were attributed to HDS. An increasing trend in HDS-hepatotoxicity was noted over time (p = .04). Camellia sinensis, Herbalife (R) products, and Garcinia cambogia, mostly used for weight loss, were the most frequently adjudicated causative agents. Mean age was 45 years (66% female). Median time to onset was 31 days. Patients presented typically with hepatocellular injury (83%) and jaundice (66%). Five cases (17%) developed acute liver failure. Compared to conventional medications and anabolic steroids, HDS hepatotoxicity cases had the highest levels of aspartate and alanine transaminase (p = .008 and p = .021, respectively), had more re-exposure events to the culprit HDS (14% vs 3% vs 0%; p = .026), and had more severe and fatal/liver transplantation outcomes (21% vs 12% vs 13%; p = .005). Compared to other DILI cohorts, less HDS hepatotoxicity cases in Latin America were hospitalized (41%).
dc.description.abstractCONCLUSIONS: HDS-hepatotoxicity in Latin-America affects mainly young women, manifests mostly with hepatocellular injury and is associated with higher frequency of accidental re-exposure. HDS hepatotoxicity is more serious with a higher chance of death/liver transplantation than DILI related to conventional drugs.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.cgh.2021.01.011
dc.identifier.eissn1542-7714
dc.identifier.issn1542-3565
dc.identifier.urihttps://doi.org/10.1016/j.cgh.2021.01.011
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93687
dc.identifier.wosidWOS:000754715100025
dc.issue.numero3
dc.language.isoen
dc.pagina.finalE563
dc.pagina.inicioE548
dc.revistaClinical gastroenterology and hepatology
dc.rightsacceso restringido
dc.subjectHerbal-Induced Liver Injury
dc.subjectHerbal and Dietary Supplements
dc.subjectDrug-Induced Liver Injury
dc.subjectLiver Toxicity
dc.subjectHepatotoxicity
dc.subjectLATINDILI Network
dc.subjectLatin America
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHerbal and Dietary Supplements-Induced Liver Injury in Latin America: Experience From the LATINDILI Network
dc.typeartículo
dc.volumen20
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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