Wnt signaling involvement in β-amyloid-dependent neurodegeneration

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dc.contributor.authorInestrosa, NC
dc.contributor.authorDe Ferrari, GV
dc.contributor.authorGarrido, JL
dc.contributor.authorAlvarez, A
dc.contributor.authorOlivares, GH
dc.contributor.authorBarría, MI
dc.contributor.authorBronfman, M
dc.contributor.authorChacón, MA
dc.date.accessioned2025-01-21T01:10:27Z
dc.date.available2025-01-21T01:10:27Z
dc.date.issued2002
dc.description.abstractAlzheimer's disease (AD) is a progressive dementia paralleled by selective neuronal death, which is probably caused by the cytotoxic effects of the amyloid-p peptide (Abeta). We have observed that Abeta-dependent neurotoxicity induces a loss of function of Wnt signaling components and that activation of this signaling cascade prevent such cytotoxic effects. Therefore we propose that compounds which mimic this signaling cascade may be candidates for therapeutic intervention in Alzheimer's patients. (C) 2002 Elsevier Science Ltd. All rights reserved.
dc.fuente.origenWOS
dc.identifier.eissn1872-9754
dc.identifier.issn0197-0186
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96685
dc.identifier.wosidWOS:000178161300009
dc.issue.numero5
dc.language.isoen
dc.pagina.final344
dc.pagina.inicio341
dc.revistaNeurochemistry international
dc.rightsacceso restringido
dc.subjectWnt signaling
dc.subjectbeta-amyloid
dc.subjectneurodegeneration
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleWnt signaling involvement in β-amyloid-dependent neurodegeneration
dc.typeartículo
dc.volumen41
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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