Association of tissue oxygen saturation levels with skeletal muscle injury in the critically ill

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dc.contributor.authorSugiya, Ryuji
dc.contributor.authorArizono, Shinichi
dc.contributor.authorHigashimoto, Yuji
dc.contributor.authorKimoto, Yuta
dc.contributor.authorShiraishi, Masashi
dc.contributor.authorMizusawa, Hiroki
dc.contributor.authorTawara, Yuichi
dc.contributor.authorShigeoka, Hironori
dc.contributor.authorBakker, Jan
dc.contributor.authorShinozaki, Koichiro
dc.date.accessioned2025-01-20T17:06:52Z
dc.date.available2025-01-20T17:06:52Z
dc.date.issued2024
dc.description.abstractThis study aimed to investigate the association between the level of tissue oxygen saturation (StO(2)) and quadriceps/skeletal muscle dysfunction, measured using the Medical Research Council (MRC) scale and ultrasonography, in critically ill patients. Thirty-four patients hospitalized at the Critical Care Medicine Center of Kindai University Hospital, between January 2022 and March 2023, were enrolled in this study. The StO(2) of the quadriceps muscle was measured via near-infrared spectroscopy. Muscle atrophy was measured by the thickness, cross-sectional area (CSA), and echo intensity of the rectus femoris (RF). These values were evaluated every alternate day until 13 days after admission or until discharge, whichever occurred first. Muscle weakness was assessed using the sum score of the MRC scale (MRC-SS), with the patient sitting at bedside. The mean age of the patients was 67.3 +/- 15.3 years, and 20 (59%) were men. Seven patients (21%) were admitted for trauma, and 27 (79%) were admitted for medical emergencies or others. The mean score for the MRC-SS was 51.0 +/- 7.9 points. RF thickness and CSA significantly decreased after day 7 (p < 0.05). There were no significant changes in StO(2) levels during hospitalization. However, there were positive correlations between the nadir StO(2) during hospitalization and MRC-SS, and changes in RF thickness and CSA at discharge (r = 0.41, p = 0.03; r = 0.37, p = 0.03; and r = 0.35, p = 0.05, respectively). StO(2) in the quadriceps muscle may be useful for predicting muscle atrophy and dysfunction in patients with critical illnesses.
dc.description.funderGrants-in-Aid for Scientific Research
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-024-55118-1
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-024-55118-1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90823
dc.identifier.wosidWOS:001177603900023
dc.issue.numero1
dc.language.isoen
dc.revistaScientific reports
dc.rightsacceso restringido
dc.subjectTissue oxygen saturation
dc.subjectUltrasonography
dc.subjectMedical Research Council (MRC) scale
dc.subjectNear-infrared spectroscopy
dc.subjectRectus femoris
dc.subjectCross-sectional area
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dc.titleAssociation of tissue oxygen saturation levels with skeletal muscle injury in the critically ill
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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