RESPONSE OF THE MATERNAL, FETAL, AND NEONATAL PITUITARY-THYROID AXIS TO THYROTROPIN-RELEASING-HORMONE

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dc.contributor.authorMOYA, F
dc.contributor.authorMENA, P
dc.contributor.authorHEUSSER, F
dc.contributor.authorFORADORI, A
dc.contributor.authorPAIVA, E
dc.contributor.authorYAZIGI, R
dc.contributor.authorMICHAUD, P
dc.contributor.authorGROSS, I
dc.date.accessioned2025-01-23T19:26:13Z
dc.date.available2025-01-23T19:26:13Z
dc.date.issued1986
dc.description.abstractThyrotropin releasing hormone (TRH) readily crosses the placenta and stimulates the fetal pituitary. We studied the response of the maternal and fetal pituitary-thyroid axes to TRH and the influence of prenatal exposure to TRH on the physiological postnatal increase in thyrotropin (TSH) and triiodothyronine (T3) in the neonate. Twenty-six pregnant women received TRH (400 or 600 .mu.g) intravenous or saline (controls) either 2 or 12 h before elective cesarean section at term. Administration of 400 .mu.g of TRH resulted in significant elevations of maternal TSH (15.7 .+-. 2.9 versus 3.2 .+-. 0.4 .mu.U/ml, p < 0.01) and prolactin (416 .+-. 94 versus 223 .+-. 41 ng/ml, p < 0.05) 2 h later. Maternal T3 remained unchanged. A higher dose of TRH (600 .mu.g) produced comparable results. Maternal administration of TRH (400 .mu.g) 2 h before delivery resulted in significant increases in fetal TSH and T3 over controls (21.1 .+-. 3.7 versus 4.8 .+-. 1.0 .mu.U/ml, and 132 .+-. 12 versus 64 .+-. 9 ng/dl, p < 0.01, respectively). Cord blood hormone levels 12 hours after TRH administration were similar to controls. Higher doses of TRH did not produce further increases in fetal TSH or T3. Control and treated neonates demonstrated similar physiological postnatal increases in TSH and T3, suggesting that prior exposure to TRH did not blunt this response. These data suggest that maternal administration of TRH is an effective way of increasing fetal T3 levels, and that this treatment does not inhibit the postnatal surge is TSH and T3.
dc.fuente.origenWOS
dc.identifier.eissn1530-0447
dc.identifier.issn0031-3998
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99582
dc.identifier.wosidWOS:A1986E253200015
dc.issue.numero10
dc.language.isoen
dc.pagina.final986
dc.pagina.inicio982
dc.revistaPediatric research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRESPONSE OF THE MATERNAL, FETAL, AND NEONATAL PITUITARY-THYROID AXIS TO THYROTROPIN-RELEASING-HORMONE
dc.typeartículo
dc.volumen20
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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