Human globozoospermia-related genes and their role in acrosome biogenesis

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dc.contributor.authorMoreno, Ricardo D.
dc.date.accessioned2025-01-20T20:20:09Z
dc.date.available2025-01-20T20:20:09Z
dc.date.issued2023
dc.description.abstractThe mammalian acrosome is a secretory vesicle attached to the sperm nucleus whose fusion with the overlying plasma membrane is required to achieve fertilization. Acrosome biogenesis starts during meiosis, but it lasts through the entire process of haploid cell differentiation (spermiogenesis). Acrosome biogenesis is a stepwise process that involves membrane traffic from the Golgi apparatus, but it also seems that the lysosome/endosome system participates in this process. Defective sperm head morphology is accompanied by defective acrosome shape and function, and patients with these characteristics are infertile or subfertile. The most extreme case of acrosome biogenesis failure is globozoospermia syndrome, which is primarily characterized by the presence of round-headed spermatozoa without acrosomes with cytoskeleton defects around the nucleus and infertility. Several genes participating in acrosome biogenesis have been uncovered using genetic deletions in mice, but only a few of them have been found to be deleted or modified in patients with globozoospermia. Understanding acrosome biogenesis is crucial to uncovering the molecular basis of male infertility and developing new diagnostic tools and assisted reproductive technologies that may help infertile patients through more effective treatment techniques.This article is categorized under:Reproductive System Diseases > Environmental FactorsInfectious Diseases > Stem Cells and DevelopmentReproductive System Diseases > Molecular and Cellular Physiology
dc.fuente.origenWOS
dc.identifier.doi10.1002/wsbm.1589
dc.identifier.issn2692-9368
dc.identifier.urihttps://doi.org/10.1002/wsbm.1589
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92564
dc.identifier.wosidWOS:000894970500001
dc.issue.numero2
dc.language.isoen
dc.revistaWires mechanisms of disease
dc.rightsacceso restringido
dc.subjectexocytosis
dc.subjectfertilization
dc.subjectspermatozoa
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHuman globozoospermia-related genes and their role in acrosome biogenesis
dc.typeartículo
dc.volumen15
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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