Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess

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dc.contributor.authorTapia-Castillo, Alejandra
dc.contributor.authorCarvajal, Cristian A.
dc.contributor.authorLopez-Cortes, Xaviera
dc.contributor.authorVecchiola, Andrea
dc.contributor.authorFardella, Carlos E.
dc.date.accessioned2025-01-20T22:09:48Z
dc.date.available2025-01-20T22:09:48Z
dc.date.issued2021
dc.description.abstractNonclassic apparent mineralocorticoid excess (NC-AME) is proposed as a novel clinical condition with a mild phenotypic spectrum that ranges from normotension to severe hypertension. This condition is mainly characterized by a high serum cortisol to cortisone ratio (F/E) and concomitant low cortisone (E), however further metabolic changes in NC-AME have not been studied. A cross-sectional study was performed in a primary-care cohort of 396 Chilean subjects, which were classified in two groups: NC-AME (n = 28) and healthy controls (n = 27). A discovery study based in untargeted metabolomics assay in serum samples from both groups was performed by UPLC-Q-TOF/MS. Global metabolomic variations were assayed by principal component analysis and further compared by orthogonal partial least-squares discriminant analysis (OPLS-DA). NC-AME subjects exhibited higher values of blood pressure, fractional excretion of potassium, and lower plasma renin activity and urinary sodium to potassium ratio. Metabolomic analyses showed 36 differentially regulated metabolites between NC-AME and control subjects. A ROC curve analyses identified eight metabolites with high discriminatory capacity between NC-AME and control subjects. Moreover, gamma-l-glutamyl-l-methionine sulfoxide and 5-sulfoxymethylfurfural, exhibited significant association with cortisone, which are potential biomarkers of NC-AME, however further assays should elucidate its biological role in setup and progression of this phenotype.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-021-96628-6
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-021-96628-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94348
dc.identifier.wosidWOS:000688551400031
dc.issue.numero1
dc.language.isoen
dc.revistaScientific reports
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNovel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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