Wheezing on admission: a marker for bronchiolitis severity and asthma development

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dc.catalogadorgjm
dc.contributor.authorAstudillo Paredes, Patricio Andrés
dc.contributor.authorRodríguez Fernández, María
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorLópez Lastra, Marcelo Andrés
dc.date.accessioned2025-05-07T14:24:37Z
dc.date.available2025-05-07T14:24:37Z
dc.date.issued2025
dc.description.abstractBackground: Supervised clustering of bronchiolitis patients, according to their clinical characteristics at hospital admission, helps predict short-term hospital outcomes and the risk of developing childhood respiratory illness. Thus, we evaluated the use of wheezing status for stratifying bronchiolitis patients. Methods: A prospective cohort study was conducted involving 668 previously healthy, full-term Chilean infants ( < 2 years old) hospitalized with bronchiolitis. Patients categorized based on their wheezing status at hospital admission were monitored during hospitalization and followed for 4 years after discharge. Results: Wheezing children presented a more severe illness requiring more oxygen during their hospital stay. Upon discharge, they were more likely to develop preschool wheezing at 12 months and asthma at 4 years of age. Among the non-wheezing, those with RSV had more severe disease. Risk factors exclusively associated with persistent asthma development for the wheezing were clinical bacterial coinfection, parental asthma history, and having had a severe bronchiolitis episode. Risk factors exclusive for non-wheezing were maternal smoking during pregnancy and severe retractions. Conclusion: Bronchiolitis patients can be categorized based on their wheezing status at hospital admission, helping predict short-term clinical outcomes and identify infants at risk of developing severe short- and long-term respiratory illnesses.
dc.format.extent10 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1038/s41390-025-04096-9
dc.identifier.urihttps://doi.org/10.1038/s41390-025-04096-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104041
dc.information.autorucEscuela de Medicina; Astudillo Paredes, Patricio Andrés; S/I; 179203
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Rodríguez Fernández, María; 0003 1966 2920; 1031920
dc.information.autorucEscuela de Medicina; Castro Rodríguez, José Antonio; 0000-0002-0708-4281; 113247
dc.information.autorucEscuela de Medicina; López Lastra, Marcelo Andrés; 0000-0002-7936-8478; 84823
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaPediatric Research
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleWheezing on admission: a marker for bronchiolitis severity and asthma development
dc.typeartículo
sipa.codpersvinculados179203
sipa.codpersvinculados1031920
sipa.codpersvinculados113247
sipa.codpersvinculados84823
sipa.trazabilidadORCID;2025-05-07
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