Acute kidney injury in critically ill patients with 2009 influenza A (H1N1) viral pneumonia: an observational study

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dc.contributor.authorNin, N.
dc.contributor.authorLorente, J. A.
dc.contributor.authorSoto, L.
dc.contributor.authorRios, F.
dc.contributor.authorHurtado, J.
dc.contributor.authorArancibia, F.
dc.contributor.authorUgarte, S.
dc.contributor.authorEchevarria, E.
dc.contributor.authorCardinal, P.
dc.contributor.authorSaldarini, F.
dc.contributor.authorBagnulo, H.
dc.contributor.authorCortes, I.
dc.contributor.authorBujedo, G.
dc.contributor.authorOrtega, C.
dc.contributor.authorFrutos, F.
dc.contributor.authorEsteban, A.
dc.date.accessioned2025-01-21T00:02:12Z
dc.date.available2025-01-21T00:02:12Z
dc.date.issued2011
dc.description.abstractTo describe the incidence, risk factors, and impact on mortality of acute kidney injury (AKI) in patients with 2009 influenza A (H1N1) viral pneumonia requiring mechanical ventilation.
dc.description.abstractObservational cohort study.
dc.description.abstractAKI was defined as risk, injury or failure, according to the RIFLE classification. Early and late AKI were defined as AKI occurring on intensive care unit (ICU) day 2 or before, or after ICU day 2, respectively. Demographic data and information on organ dysfunction were collected daily.
dc.description.abstractOf 84 patients, AKI developed in 43 patients (51%). Twenty (24%) needed renal replacement therapy. Early and late AKI were found in 28 (33%) and 15 (18%) patients, respectively. Patients with AKI, as compared with patients without AKI, had higher Acute Physiology and Chronic Health Evaluation (APACHE) II score and ICU mortality (72% versus 39%, p < 0.01) and presented on admission more marked cardiovascular, respiratory, and hematological dysfunction. Patients with early but not late AKI presented on admission higher APACHE II score and more marked organ dysfunction, as compared with patients without AKI. ICU mortality was higher in late versus early AKI (93% versus 61%, p < 0.001). On multivariate analysis, only APACHE II score and late but not early AKI [odds ratio (OR) 1.1 (95% confidence interval 1.0-1.1) and 15.1 (1.8-130.7), respectively] were associated with mortality.
dc.description.abstractAKI is a frequent complication of 2009 influenza A (H1N1) viral pneumonia. AKI developing after 2 days in ICU appears to be associated with different risk factors than early AKI, and is related to a higher mortality rate.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00134-011-2167-7
dc.identifier.eissn1432-1238
dc.identifier.issn0342-4642
dc.identifier.urihttps://doi.org/10.1007/s00134-011-2167-7
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95414
dc.identifier.wosidWOS:000289291900006
dc.issue.numero5
dc.language.isoen
dc.pagina.final774
dc.pagina.inicio768
dc.revistaIntensive care medicine
dc.rightsacceso restringido
dc.subjectAcute kidney injury
dc.subjectH1N1 influenza
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAcute kidney injury in critically ill patients with 2009 influenza A (H1N1) viral pneumonia: an observational study
dc.typeartículo
dc.volumen37
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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