NERVE REGULATION OF CLASS-I AND CLASS-II-ASYMMETRIC FORMS OF ACETYLCHOLINESTERASE IN RAT SKELETAL-MUSCLES

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dc.contributor.authorFADIC, R
dc.contributor.authorINESTROSA, NC
dc.date.accessioned2025-01-23T19:24:03Z
dc.date.available2025-01-23T19:24:03Z
dc.date.issued1989
dc.description.abstractTwo classes of collagen-tailed, asymmetric forms (A-forms) of acetylcholinesterase (AChE) have been described in skeletal muscles of vertebrates. They are distinguished by their different solubilization requirements: class I A-forms are solubilized in the presence of high salt, whereas class II A-forms require in addition a chelating agent for solubilization. We report here that class II A-forms are less sensitive to nerve section than are class I A-forms. The latter form decreases faster and to a lower level of activity after denervation. The decay of both AChE classes is more rapidly in short-stump nerves than in long ones. The effect of nerve section on class II A-forms appears to be dependent on the particular muscle group being studied. Both classes of A-forms reappear after muscle reinervation, but the class I A-forms recovered earlier. More interestingly, both classes of A-forms increase in normally innervated skeletal muscles after contralateral nerve injury. In this case, however, the class II A-forms change first. Muscular disuse induced by contralateral tenotomy is also followed by a rise in class II A-forms. Our results, showing differences in response and flexibility in the changes of the two classes of A-forms in several experimental conditions, represent a relevant contribution to the understanding of the regulation and functional role of the asymmetric forms of AChE in vertebrate skeletal muscles.
dc.fuente.origenWOS
dc.identifier.eissn1097-4547
dc.identifier.issn0360-4012
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99302
dc.identifier.wosidWOS:A1989U782400009
dc.issue.numero4
dc.language.isoen
dc.pagina.final455
dc.pagina.inicio449
dc.revistaJournal of neuroscience research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNERVE REGULATION OF CLASS-I AND CLASS-II-ASYMMETRIC FORMS OF ACETYLCHOLINESTERASE IN RAT SKELETAL-MUSCLES
dc.typeartículo
dc.volumen22
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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