Nitroaryl-1,4-dihydropyridines as antioxidants against rat liver microsomes oxidation induced by iron/ascorbate, Nitrofurantoin and naphthalene

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dc.contributor.authorLetelier, Maria Eugenia
dc.contributor.authorEntrala, Paz
dc.contributor.authorLopez Alarcon, Camilo
dc.contributor.authorGonzalez Lira, Victor
dc.contributor.authorMolina Berrios, Alfredo
dc.contributor.authorCortes Troncoso, Juan
dc.contributor.authorJara Sandoval, Jose
dc.contributor.authorSantander, Paola
dc.contributor.authorNunez Vergara, Luis
dc.date.accessioned2024-01-10T12:06:57Z
dc.date.available2024-01-10T12:06:57Z
dc.date.issued2007
dc.description.abstract1,4-Dihydropyridines (DHPs) used in the treatment of cardiovascular diseases, are calcium channel antagonists and also antioxidant agents. These drugs are metabolized through cytochrome P-450 oxidative system, majority localized in the hepatic endoplasmic reticulum. Several lipophilic drugs generate oxidative stress to be metabolized by this cellular system. Thus, DHP antioxidant properties may prevent the oxidative stress associated with hepatic biotransformation of drugs.
dc.description.abstractIn this work, we tested the antioxidant capacity of several synthetic nitro-phenyl-DHPs. These compounds (I-IV) inhibited the microsomal lipid peroxidation, UDPGT oxidative activation and microsomal thiols oxidation; all phenomena induced by Fe3+/ascorbate, a generator system of oxygen free radicals. As the same manner, these compounds inhibited the oxygen consumption induced by Cu2+/ascorbate in the absence of microsomes. Furthermore, compound III (2,6-dimethyl-4-(4-nitro phenyl)-1,4-dihydropyridin-3,5-ethyldicarboxylate) and compound V (N-ethyl-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridin-3,5-methyl-dicarboxylate) inhibited the microsomal lipid peroxidation induced by Nitrofurantoin and naphthalene in the presence of NADPH. Oxidative stress induced on endoplasmic reticulum may alter the biotransformation of drugs, so, modifying their plasmatic concentrations and therapeutic effects. When drugs which are activated by biotransformation are administered together with antioxidant drugs, such as DHPs, oxidative stress induced in situ may be prevented. (C) 2007 Elsevier Ltd. All rights reserved.
dc.fechaingreso.objetodigital11-04-2024
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.tiv.2007.06.001
dc.identifier.issn0887-2333
dc.identifier.pubmedidMEDLINE:17669617
dc.identifier.urihttps://doi.org/10.1016/j.tiv.2007.06.001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76226
dc.identifier.wosidWOS:000251558100029
dc.information.autorucQuímica;López-Alarcón C;S/I;1004308
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1618
dc.pagina.inicio1610
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaTOXICOLOGY IN VITRO
dc.rightsacceso restringido
dc.subjectaryl-1,4-dihydropyridines-antioxidant agents
dc.subjectcalcium channel antagonist-oxidative stress
dc.subjectaryl-1,4-dihydropyridines-ROS
dc.subjectCALCIUM-CHANNEL BLOCKERS
dc.subjectLIPID-PEROXIDATION
dc.subjectPHOSPHATIDYLCHOLINE LIPOSOMES
dc.subjectDIHYDROPYRIDINE DERIVATIVES
dc.subjectLDL OXIDATION
dc.subjectNIFEDIPINE
dc.subjectINHIBITION
dc.subjectREACTIVITY
dc.subjectCELLS
dc.subject1,4-DIHYDROPYRIDINES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNitroaryl-1,4-dihydropyridines as antioxidants against rat liver microsomes oxidation induced by iron/ascorbate, Nitrofurantoin and naphthalene
dc.typeartículo
dc.volumen21
sipa.codpersvinculados1004308
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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