HISTOLOGIC ASSESSMENT OF THE AGE OF RECENT BRAIN INFARCTS IN MAN

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dc.contributor.authorCHUAQUI, R
dc.contributor.authorTAPIA, J
dc.date.accessioned2025-01-23T19:21:39Z
dc.date.available2025-01-23T19:21:39Z
dc.date.issued1993
dc.description.abstractIn order to design a dating system based on the microscopic picture of brain infarcts of recent onset, we performed the histological examination of 31 infarcts covering the first 4 weeks of evolution in 30 autopsy cases. The date of the cerebral vascular accident was clinically established in every case. There were 13 men and 17 women with a mean age of 65 years. Hemorrhagic infarcts were found in 15 cases and anemic infarcts in 16 cases. Based on the histological features four periods were identified: the first period, from day 1 through day 4, was characterized by the predominance of eosinophilic neurons and necrotic oligodendrocytes; the second period, from day 5 through day 7, differed from the first by the appearance of macrophages and of newly formed blood vessels; the third period, from day 8 through day 14, showed neuronal ghosts, macrophages, astrocytic proliferation, gemistocytes, and absence of neutrophils; and in the fourth period, from day 15 through day 27, there were no eosinophilic neurons, and neither necrotic oligodendrocytes nor myelin in the central portion of the infarct were identified. By assessing the histological features and accurately correlating the findings with the corresponding clinical data, we have been able to describe four distinct microscopic pattems of the first month of evolution of brain infarcts. The present findings may be considered useful morphological clues to better characterize the early evolutional phase of brain infarcts in humans.
dc.fuente.origenWOS
dc.identifier.eissn1554-6578
dc.identifier.issn0022-3069
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98831
dc.identifier.wosidWOS:A1993LW55700006
dc.issue.numero5
dc.language.isoen
dc.pagina.final489
dc.pagina.inicio481
dc.revistaJournal of neuropathology and experimental neurology
dc.rightsacceso restringido
dc.subjectBRAIN INFARCT
dc.subjectHISTOLOGIC DATING
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHISTOLOGIC ASSESSMENT OF THE AGE OF RECENT BRAIN INFARCTS IN MAN
dc.typeartículo
dc.volumen52
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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