Active surveillance is a feasible and safe strategy in selected patients with papillary thyroid cancer and suspicious cervical lymph nodes detected after thyroidectomy

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dc.article.number106217
dc.contributor.authorSolorzano M.
dc.contributor.authorLustig N.
dc.contributor.authorMosso L.
dc.contributor.authorEspinoza M.
dc.contributor.authorSantana R.
dc.contributor.authorGonzalez H.
dc.contributor.authorMontero P.H.
dc.contributor.authorCruz F.
dc.contributor.authorSolar A.
dc.contributor.authorDominguez J.M.
dc.contributor.otherNCD Risk Factor Collaboration (NCD-RisC)
dc.date.accessioned2024-08-15T08:00:19Z
dc.date.available2024-08-15T08:00:19Z
dc.date.issued2024
dc.description.abstractObjective: After initial treatment, up to 30% of patients with papillary thyroid cancer (PTC) have incomplete response, mainly cervical lymph node (LN) disease. Previous studies have suggested that active surveillance (AS) is a possible option for these patients. Our aim was to report the results of AS in patients with PTC and cervical LN disease. Materials and methods: In this retrospective observational study, we included adult patients treated and followed for PTC, who presented with cervical LN disease and were managed with AS. Growth was defined as an increase ≥ 3mm in either diameter. Results: We included 32 patients: 27 (84.4%) women, age of 39 ± 14 years, all initially treated with total thyroidectomy, and 22 (69%) with therapeutic neck dissection. Cervical LN disease was diagnosed 1 year (0.3-12.6) after initial management, with a diameter of 9.0 mm (6.0-19.0). After a median AS of 4.3 years (0.6-14.1), 4 (12.5%) patients had LNgrowth: 2 (50%) of whom were surgically removed, 1 (25%) was effectively treated with radiotherapy, and 1 (25%) had a scheduled surgery. Tg increase was the only predictive factor of LN growth evaluated as both the delta Tg (p < 0.0366) and percentage of Tg change (p < 0.0140). None of the included patients died, had local complications due to LN growth or salvage therapy, or developed distant metastases during follow-up. Conclusion: In selected patients with PTC and suspicious cervical LNs diagnosed after initial treatment, AS is a feasible and safe strategy as it allows effective identification and treatment of the minority of patients who progress.
dc.description.funderNational Research and Development Agency of Chile, National Doctoral Scholarship
dc.format.extent1 página
dc.fuente.origenScopus
dc.identifier.doi10.20945/2359-4292-2023-0146
dc.identifier.eissn1365-2206
dc.identifier.issn23594292
dc.identifier.pubmedid15880187
dc.identifier.scopusidSCOPUS_ID:85192313067
dc.identifier.urihttps://doi.org/10.20945/2359-4292-2023-0146
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87461
dc.identifier.wosidWOS:001243819500005
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero20
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final2901
dc.pagina.inicio2885
dc.relation.ispartof92nd Meeting and Expo of the Endocrine Society (ENDO 2010), JUN 19-22, 2010, San Diego, CA
dc.revistaArchives of endocrinology and metabolism
dc.rightsacceso abierto
dc.subjectactive surveillance
dc.subjectlocoregional structural disease
dc.subjectPapillary thyroid carcinoma
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleActive surveillance is a feasible and safe strategy in selected patients with papillary thyroid cancer and suspicious cervical lymph nodes detected after thyroidectomy
dc.typeartículo
dc.volumen68
sipa.codpersvinculados88201
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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