Occurrence of area postrema syndrome during follow-up: phenotype and influence over NMOSD activity in LATAM in real-world settings

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dc.contributor.authorPestchanker, Claudia
dc.contributor.authorCortez, Brenda Bertado
dc.contributor.authorPeixoto, Marco A. Lana
dc.contributor.authorGortari, Jose Ignacio
dc.contributor.authorSuarez, Sheila Castro
dc.contributor.authorZamalloa, Cesar Caparo
dc.contributor.authorGaliana, Graciana
dc.contributor.authorPenalver, Francisco
dc.contributor.authorMarques, Vanesa Daccach
dc.contributor.authorMessias, Katharina
dc.contributor.authorGalleguillos, Lorna
dc.contributor.authorGarcia, Fernando
dc.contributor.authorRojas, Juan I.
dc.contributor.authorPatrucco, Liliana
dc.contributor.authorCristiano, Edgardo
dc.contributor.authorTkachuk, Veronica
dc.contributor.authorLiwacki, Susana
dc.contributor.authorCorreale, Jorge
dc.contributor.authorMarrodan, Mariano
dc.contributor.authorYsraelit, Maria C.
dc.contributor.authorVrech, Carlos
dc.contributor.authorDeri, Norma
dc.contributor.authorLeguizamon, Felisa
dc.contributor.authorTavolini, Dario
dc.contributor.authorMainella, Carolina
dc.contributor.authorZanga, Gisela
dc.contributor.authorSerena, Marina Alonso
dc.contributor.authorCiampi, Ethel
dc.contributor.authorSoares Neto, Herval Ribeiro
dc.contributor.authorLopez, Pablo
dc.contributor.authorContentti, Edgar Carnero
dc.date.accessioned2025-01-20T17:05:33Z
dc.date.available2025-01-20T17:05:33Z
dc.date.issued2024
dc.description.abstractIntroductionWe aimed to assess the frequency, duration, and severity of area postrema syndrome (APS) during follow-up in neuromyelitis optica spectrum disorder (NMOSD) patients, as well as its association with inflammatory activity and prognostic factors of APS severity in a real-world setting.MethodsWe conducted a retrospective study on a cohort of Latin American (LATAM) NMOSD patients who had experienced APS during their follow-up. Patients from Mexico, Peru, Brazil, Colombia, Panama, Chile and Argentina patients who met 2015 NMOSD criteria were included. We evaluated data on symptom type (nausea, vomiting and/or hiccups), frequency, duration, severity (measured by APS severity scale), association with other NMOSD core relapses, and acute treatments (symptomatic and immunotherapy or plasmapheresis). Logistic regression was conducted to evaluate factors associated with APS severity (vs. mild-moderate).ResultsOut of 631 NMOSD patients, 116 (18.3%) developed APS during their follow-up. The most common APS phenotype was severe. Inflammatory activity (i.e., relapses) significantly decreased after the onset of APS. Half of the patients experienced isolated APS with a median duration of 10 days, and the most frequently used acute treatment was IV steroids. All three symptoms were present in 44.6% of the patients. APS symptoms resolved following immunotherapy. Logistic regression did not identify independent factors associated with the severity of APS.ConclusionsOur findings indicate that 18.3% of NMOSD patients developed APS during the follow-up period, with most patients fulfilling criteria for severe APS. The inflammatory activity decreased after the onset of APS compared to the previous year.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00415-024-12371-8
dc.identifier.eissn1432-1459
dc.identifier.issn0340-5354
dc.identifier.urihttps://doi.org/10.1007/s00415-024-12371-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90734
dc.identifier.wosidWOS:001204065400001
dc.issue.numero7
dc.language.isoen
dc.pagina.final4299
dc.pagina.inicio4292
dc.revistaJournal of neurology
dc.rightsacceso restringido
dc.subjectArea postrema syndrome
dc.subjectNMOSD
dc.subjectPhenotype
dc.subjectSeverity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOccurrence of area postrema syndrome during follow-up: phenotype and influence over NMOSD activity in LATAM in real-world settings
dc.typeartículo
dc.volumen271
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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